Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6615852 | 0.86 | PDE4A (0.50) | ALDH1A1KDM4ESMN1; SMN2RAB9AHSD17B10 | |
| SCHEMBL6619842 | 0.83 | HSD17B10 (0.40) | ALDH1A1KDM4ESMN1; SMN2RAB9AHSD17B10 | |
| SCHEMBL15690134 | 0.82 | KDM4E (0.45) | ALDH1A1KDM4ESMN1; SMN2RAB9AHSD17B10 | |
| SCHEMBL15538674 | 0.82 | PDE10A (0.45) | ALDH1A1KDM4ESMN1; SMN2HSD17B10NTRK1 | |
| SCHEMBL6617769 | 0.76 | HPGD (0.47) | ALDH1A1KDM4ESMN1; SMN2RAB9AMAPT | |
| SCHEMBL18817005 | 0.75 | CDK5 (0.51) | ALDH1A1KDM4ESMN1; SMN2RAB9AMAPT | |
| SCHEMBL15900327 | 0.73 | ALDH1A1 (0.55) | ALDH1A1KDM4ESMN1; SMN2RAB9AHSD17B10 | |
| SCHEMBL27197675 | 0.73 | PDE4A (0.49) | ALDH1A1KDM4ESMN1; SMN2RAB9AHSD17B10 | |
| SCHEMBL15833311 | 0.73 | KDM4E (0.41) | ALDH1A1KDM4ESMN1; SMN2RAB9AMAPT | |
| SCHEMBL15690003 | 0.72 | KDM4E (0.47) | ALDH1A1KDM4ESMN1; SMN2KMT2ANTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2854804-B1 | PYRROLIDINO HETEROCYCLES | HOFFMANN LA ROCHE (CH) | 2019-11-20 | — | — | EP | disclosed |
| US-10399985-B2 | (Hetero)aryl imidazoles/pyrazoles for treatment of neurological disorders | HOFFMANN-LA ROCHE INC. (US) | 2019-09-03 | — | — | US | disclosed |
| EP-3099690-B1 | (HETERO)ARYL IMIDAZOLES/PYRAZOLES FOR TREATMENT OF NEUROLOGICAL DISORDERS | HOFFMANN LA ROCHE (CH) | 2019-08-28 | — | — | EP | disclosed |
| US-9617271-B2 | Triazolo compounds | HOFFMANN-LA ROCHE INC. (US) | 2017-04-11 | — | — | US | disclosed |
| US-9540384-B2 | Pyrrolidino heterocycles | HOFFMANN-LA ROCHE, INC. (US) | 2017-01-10 | — | — | US | disclosed |
| EP-3099690-A1 | (HETERO)ARYL IMIDAZOLES/PYRAZOLES FOR TREATMENT OF NEUROLOGICAL DISORDERS | F. Hoffmann-La Roche AG (CH) | 2016-12-07 | — | — | EP | disclosed |
| US-20160333018-A1 | (HETERO)ARYL IMIDAZOLES/PYRAZOLES FOR TREATMENT OF NEUROLOGICAL DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 2016-11-17 | — | — | US | disclosed |
| EP-2916842-B1 | TRIAZOLO COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2016-10-19 | — | — | EP | disclosed |
| EP-2916842-A1 | TRIAZOLO COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2015-09-16 | — | — | EP | disclosed |
| US-20150232472-A1 | TRIAZOLO COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2015-08-20 | — | — | US | disclosed |
| WO-2015113980-A1 | (HETERO)ARYL IMIDAZOLES/PYRAZOLES FOR TREATMENT OF NEUROLOGICAL DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2015-08-06 | — | — | WO | disclosed |
| EP-2854804-A1 | PYRROLIDINO HETEROCYCLES | F. Hoffmann-La Roche AG (CH) | 2015-04-08 | — | — | EP | disclosed |
| US-20150087644-A1 | PYRROLIDINO HETEROCYCLES | HOFFMANN-LA ROCHE INC. (US) | 2015-03-26 | — | — | US | disclosed |
| WO-2014072261-A1 | TRIAZOLO COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2014-05-15 | — | — | WO | disclosed |
| WO-2013178569-A1 | PYRROLIDINO HETEROCYCLES | F. HOFFMANN-LA ROCHE AG (CH) | 2013-12-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150087644-A1 | PYRROLIDINO HETEROCYCLES | PDE3A, PDE3B, PDE2A | ALDH1A1 159/4885KDM4E 1810/4885SMN1; SMN2 2959/4885 |
| US-20150232472-A1 | TRIAZOLO COMPOUNDS | GRIK5, NLN, GRIN2C | ALDH1A1 605/4885KDM4E 4142/4885SMN1; SMN2 60/4885 |
| US-10399985-B2 | (Hetero)aryl imidazoles/pyrazoles for treatment of neurological disorders | GRIN2B, MAOB, GRIN2A | ALDH1A1 259/4885KDM4E 2694/4885SMN1; SMN2 81/4885 |
| US-20160333018-A1 | (HETERO)ARYL IMIDAZOLES/PYRAZOLES FOR TREATMENT OF NEUROLOGICAL DISORDERS | GRIN2B, MAOB, GRIN2A | ALDH1A1 259/4885KDM4E 2694/4885SMN1; SMN2 81/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.