Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15549250 | 1.00 | BACE2 (0.35) | BACE2BACE1 | |
| SCHEMBL15536755 | 0.84 | BACE1 (0.35) | BACE2BACE1 | |
| SCHEMBL15536752 | 0.84 | BACE1 (0.35) | BACE2BACE1 | |
| SCHEMBL2589589 | 0.79 | BACE1 (0.37) | BACE2BACE1 | |
| SCHEMBL2589584 | 0.79 | BACE1 (0.37) | BACE2BACE1 | |
| SCHEMBL1979501 | 0.77 | BACE1 (0.31) | BACE2BACE1 | |
| SCHEMBL1977445 | 0.77 | BACE1 (0.40) | BACE2BACE1 | |
| SCHEMBL1977447 | 0.77 | BACE1 (0.40) | BACE2BACE1 | |
| SCHEMBL1979385 | 0.76 | BACE1 (0.32) | BACE2BACE1 | |
| SCHEMBL1975419 | 0.76 | BACE1 (0.34) | BACE2BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2855469-B1 | 5-AMINO[1,4]THIAZINES AS BACE 1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2019-06-19 | — | — | EP | disclosed |
| US-9273042-B2 | 5-amino[1,4]thiazines as BACE 1 inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2016-03-01 | — | — | US | disclosed |
| US-20150141413-A1 | 5-AMINO[1,4]THIAZINES AS BACE 1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2015-05-21 | — | — | US | disclosed |
| EP-2855469-A1 | 5-AMINO[1,4]THIAZINES AS BACE 1 INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2015-04-08 | — | — | EP | disclosed |
| WO-2013174781-A1 | 5-AMINO[1,4]THIAZINES AS BACE 1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-11-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150141413-A1 | 5-AMINO[1,4]THIAZINES AS BACE 1 INHIBITORS | BACE1, BACE2, PSEN1 | BACE2 2/4885BACE1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.