Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Indole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR known ✓ | Q92847 | 1/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.71 |
| ▸ | CA1 | P00915 | 1/20 | 0.71 |
| ▸ | CA2 | P00918 | 1/20 | 0.71 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.71 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.71 |
| ▸ | ITGAL | P20701 | 1/20 | 0.71 |
| ▸ | CA4 | P22748 | 1/20 | 0.71 |
| ▸ | CA6 | P23280 | 1/20 | 0.71 |
| ▸ | AHR | P35869 | 1/20 | 0.71 |
| ▸ | ADK | P55263 | 1/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.48 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.47 |
| ▸ | WNT3A | P56704 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Indole SCHEMBL8692212 | 1.00 | TRPA1 (0.71) | TRPA1CA1CA2ITGB2ICAM1 | |
| Indole SCHEMBL28064106 | 1.00 | TRPA1 (0.71) | TRPA1CA1CA2ITGB2ICAM1 | |
| Naphthalene SCHEMBL29066893 | 0.98 | TRPA1 (0.68) | TRPA1CA1CA2ITGB2ICAM1 | |
| Indole SCHEMBL14576774 | 0.98 | TRPA1 (0.68) | TRPA1CA1CA2ITGB2ICAM1 | |
| Indole SCHEMBL14576595 | 0.98 | TRPA1 (0.68) | TRPA1CA1CA2ITGB2ICAM1 | |
| Indole SCHEMBL14576591 | 0.98 | TRPA1 (0.68) | TRPA1CA1CA2ITGB2ICAM1 | |
| Indole SCHEMBL14576777 | 0.98 | TRPA1 (0.68) | TRPA1CA1CA2ITGB2ICAM1 | |
| Indole SCHEMBL14576309 | 0.98 | TRPA1 (0.68) | TRPA1CA1CA2ITGB2ICAM1 | |
| Indole SCHEMBL27509171 | 0.94 | TRPA1 (0.74) | TRPA1CA1CA2ITGB2ICAM1 | |
| Indole SCHEMBL9420911 | 0.93 | TRPA1 (0.61) | TRPA1CA1CA2ITGB2ICAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 6377 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12633376-B2 | System and method for risk assessment of autism spectrum disorder | TATA CONSULTANCY SERVICES LIMITED (IN) | 2026-05-19 | — | — | US | claimed |
| CN-122038204-A | High-lead-resistance growth-promoting bacillus subtilis Pb737 and application thereof | 云南农业大学 | 2026-05-15 | — | — | CN | claimed |
| EP-4728050-A1 | CULTURED AVOCADO CELLS AND A FOOD PRODUCT COMPRISING THE SAME | Teknologian Tutkimuskeskus VTT OY (FI) | 2026-04-22 | — | — | EP | claimed |
| EP-4710768-A1 | BACILLUS VELEZENSIS STRAIN VM02, A STIMULATING AGENT FOR THE GROWTH AND PRODUCTION OF HORTICULTURAL CROPS AND THE CONTROL OF PHYTOPATHOGENIC FUNGI | Vellsam Materias Bioactivas, SL (ES) | 2026-03-18 | — | — | EP | claimed |
| US-12564190-B2 | Biobased herbicide enhancer agent and method for using the same | FYTEKO SA (BE) | 2026-03-03 | — | — | US | claimed |
| US-12553055-B2 | Auxin-inducible degron system kit and use thereof | INTER-UNIVERSITY RESEARCH INSTITUTE CORPORATION RESEARCH ORGANIZATION OF INFORMATION AND SYSTEMS (JP) | 2026-02-17 | — | — | US | claimed |
| EP-4689136-A1 | ENGINEERED CSSDNA PRODUCTION HOSTS AND PHAGEMIDS | Kano Therapeutics Inc. (US) | 2026-02-11 | — | — | EP | claimed |
| US-20250367676-A1 | SYSTEMS AND METHODS FOR EXTRACTING AND ISOLATING PURIFIED WHEAT EMBRYO PRODUCTS | TRITICA BIOSCIENCES LLC (US) | 2025-12-04 | — | — | US | claimed |
| US-20250367246-A1 | IMMUNOMODULATORY COMPOSITIONS COMPRISING MICROBIAL ENTITIES | SOLAREA BIO INC (US) | 2025-12-04 | — | — | US | claimed |
| EP-4651882-A1 | MICROBIOME INGREDIENT COMBINATION FOR LOWERING UREMIC TOXINS IN CARDIOMETABOLIC OR NEURODEGENERATIVE CONDITIONS | Société des Produits Nestlé S.A. (CH) | 2025-11-26 | — | — | EP | claimed |
| US-4780987-A | Method for the preparation of hydrated, pregerminated seeds in gel capsules | PLANT GENETICS, INC. (US) | 1988-11-01 | — | — | US | claimed |
| EP-0270120-A2 | A process for breaking genetic linkage | DNA PLANT TECHNOLOGY CORPORATION (under the laws of the state of Delaware) (US) | 1988-06-08 | — | — | EP | claimed |
| US-4734369-A | DEVELOPING GENETICALLY VARIANT STRAINS OF PLANTS | CAMPBELL SOUP COMPANY (US) | 1988-03-29 | — | — | US | claimed |
| EP-0256165-A1 | Process for regenerating corn | SUNGENE TECHNOLOGIES CORPORATION (US) | 1988-02-24 | — | — | EP | claimed |
| EP-0256682-A2 | Plant treatment | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1988-02-24 | — | — | EP | claimed |
| EP-0236444-A4 | HYDRATED, PREGERMINATED SEEDS IN GEL CAPSULES. | PLANT GENETICS INC (US) | 1988-02-15 | — | — | EP | claimed |
| EP-0236444-A1 | HYDRATED, PREGERMINATED SEEDS IN GEL CAPSULES. | PLANT GENETICS INC (US) | 1987-09-16 | — | — | EP | claimed |
| WO-1987001258-A1 | HYDRATED, PREGERMINATED SEEDS IN GEL CAPSULES | PLANT GENETICS, INC. (US) | 1987-03-12 | — | — | WO | claimed |
| EP-0175577-A2 | Microchemiluminescent assay system | Kiel, Jonathan L (US) | 1986-03-26 | — | — | EP | claimed |
| US-4361984-A | Micropropagation of plant material | KELOWNA NURSERIES LTD. (CA) | 1982-12-07 | — | — | US | claimed |