Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 15/20 | 0.66 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.66 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.58 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.58 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.58 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.57 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15553414 | 0.90 | KIT (0.69) | KITDYRK1AAAK1MAP3K11PIK3CA | |
| SCHEMBL15553843 | 0.88 | KIT (0.80) | KITDYRK1AAAK1MAP3K11PIK3CA | |
| SCHEMBL722517 | 0.83 | MAP3K11 (0.79) | KITDYRK1AAAK1NTRK1MAP3K11 | |
| SCHEMBL12763552 | 0.81 | AAK1 (0.62) | KITDYRK1AAAK1NTRK1SLC2A1 | |
| SCHEMBL15833894 | 0.81 | KIT (1.00) | KITDYRK1AAAK1NTRK1PIK3CA | |
| SCHEMBL15560067 | 0.80 | KIT (0.69) | KITDYRK1AMAP3K11PIK3CA | |
| SCHEMBL7910200 | 0.79 | KIT (0.58) | KITDYRK1AAAK1NTRK1PIK3CA | |
| SCHEMBL15553965 | 0.79 | KIT (0.66) | KITDYRK1AAAK1MAP3K11PIK3CA | |
| SCHEMBL15554558 | 0.78 | KIT (0.52) | KITNTRK1PIK3CA | |
| SCHEMBL15554959 | 0.78 | MAP4K1 (0.66) | KITDYRK1AAAK1MAP3K11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014004863-A2 | COMPOUNDS, COMPOSITIONS, AND THERAPEUTIC USES THEREOF | ALZHEIMER'S INSTITUTE OF AMERICA, INC. (US) | 2014-01-03 | — | — | WO | claimed |
| WO-2014004863-A2 | COMPOUNDS, COMPOSITIONS, AND THERAPEUTIC USES THEREOF | ALZHEIMER'S INSTITUTE OF AMERICA, INC. (US) | 2014-01-03 | — | — | WO | disclosed |