Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 15/20 | 0.58 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.58 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.57 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.54 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.54 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.52 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7903775 | 0.89 | KIT (0.73) | KITDYRK1APIK3CASLC2A1AAK1 | |
| SCHEMBL7905848 | 0.85 | KIT (0.60) | KITDYRK1APIK3CASLC2A1AAK1 | |
| SCHEMBL7899036 | 0.84 | KIT (0.63) | KITDYRK1ANTRK1PIK3CASLC2A1 | |
| SCHEMBL7907903 | 0.83 | KIT (0.70) | KITDYRK1APIK3CASLC2A1 | |
| SCHEMBL7910174 | 0.81 | MAP3K11 (0.60) | KITDYRK1APIK3CASLC2A1MAP4K1 | |
| SCHEMBL12763552 | 0.80 | AAK1 (0.62) | KITDYRK1ANTRK1SLC2A1AAK1 | |
| SCHEMBL722517 | 0.80 | MAP3K11 (0.79) | KITDYRK1ANTRK1AAK1 | |
| SCHEMBL7912925 | 0.79 | MAP3K11 (0.51) | NTRK1MAP4K1 | |
| SCHEMBL15553827 | 0.79 | KIT (0.66) | KITDYRK1ANTRK1PIK3CASLC2A1 | |
| SCHEMBL12066048 | 0.79 | MAP4K1 (0.65) | KITDYRK1ANTRK1MAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010068483-A2 | MLK INHIBITORS AND METHODS OF USE | UNIVERSITY OF ROCHESTER (US) | 2010-06-17 | — | — | WO | disclosed |