Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | MET | P08581 | 4/20 | 0.50 |
| ▸ | KDR | P35968 | 4/20 | 0.50 |
| ▸ | IGF1R | P08069 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | INSR | P06213 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15549630 | 0.92 | TP53 (0.48) | TP53HSD17B10METKDRIGF1R | |
| SCHEMBL15559994 | 0.91 | TP53 (0.56) | TP53HSD17B10METKDRIGF1R | |
| SCHEMBL15559245 | 0.84 | TP53 (0.60) | TP53HSD17B10METKDRIGF1R | |
| SCHEMBL15559122 | 0.83 | MET (0.61) | TP53HSD17B10METKDRIGF1R | |
| SCHEMBL27936346 | 0.81 | TP53 (0.60) | TP53HSD17B10METKDRIGF1R | |
| SCHEMBL15559382 | 0.80 | MET (0.64) | METKDRIGF1RAURKAJAK2 | |
| SCHEMBL30441501 | 0.80 | PTGFR (0.57) | TP53HSD17B10METKDRIGF1R | |
| SCHEMBL2952839 | 0.80 | PTGFR (0.57) | TP53HSD17B10METKDRIGF1R | |
| SCHEMBL15548809 | 0.79 | MAPT (0.58) | TP53HSD17B10METKDRIGF1R | |
| SCHEMBL15560850 | 0.77 | MET (0.77) | METKDRIGF1RAURKAJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2879677-B1 | SUBSTITUTED PYRAZOLONE COMPOUNDS AND METHODS OF USE | CALITOR SCIENCES LLC (US) | 2017-06-14 | — | — | EP | disclosed |
| EP-2879676-B1 | SUBSTITUTED PYRAZOLONE COMPOUNDS AND METHODS OF USE | CALITOR SCIENCES LLC (US) | 2017-06-14 | — | — | EP | disclosed |
| US-9326975-B2 | Substituted pyrazolone compounds and methods of use | SUNSHINE LAKE PHARMA CO., LTD (CN) | 2016-05-03 | — | — | US | disclosed |
| EP-2879676-A1 | SUBSTITUTED PYRAZOLONE COMPOUNDS AND METHODS OF USE | Calitor Sciences, LLC (US) | 2015-06-10 | — | — | EP | disclosed |
| EP-2879677-A2 | SUBSTITUTED PYRAZOLONE COMPOUNDS AND METHODS OF USE | Calitor Sciences, LLC (US) | 2015-06-10 | — | — | EP | disclosed |
| US-20150141463-A1 | SUBSTITUTED PYRAZOLONE COMPOUNDS AND METHODS OF USE | CALITOR SCIENCES, LLC (US) | 2015-05-21 | — | — | US | disclosed |
| US-8975282-B2 | Substituted pyrazolone compounds and methods of use | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2015-03-10 | — | — | US | disclosed |
| US-8969388-B1 | Substituted pyrazolone compounds and methods of use | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2015-03-03 | — | — | US | disclosed |
| US-20150050239-A1 | SUBSTITUTED PYRAZOLONE COMPOUNDS AND METHODS OF USE | CALITOR SCIENCES, LLC (US) | 2015-02-19 | — | — | US | disclosed |
| US-20150037280-A1 | SUBSTITUTED PYRAZOLONE COMPOUNDS AND METHODS OF USE | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2015-02-05 | — | — | US | disclosed |
| WO-2014022117-A1 | SUBSTITUTED PYRAZOLONE COMPOUNDS AND METHODS OF USE | CALITOR SCIENCES, LLC (US) | 2014-02-06 | — | — | WO | disclosed |
| WO-2014022116-A2 | SUBSTITUTED PYRAZOLONE COMPOUNDS AND METHODS OF USE | CALITOR SCIENCES, LLC (US) | 2014-02-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150037280-A1 | SUBSTITUTED PYRAZOLONE COMPOUNDS AND METHODS OF USE | MKI67, PRKACA, PRKDC | TP53 47/4885HSD17B10 2613/4885MET 796/4885 |
| US-20150141463-A1 | SUBSTITUTED PYRAZOLONE COMPOUNDS AND METHODS OF USE | MKI67, PRKACA, PRKDC | TP53 47/4885HSD17B10 2613/4885MET 796/4885 |
| US-20150050239-A1 | SUBSTITUTED PYRAZOLONE COMPOUNDS AND METHODS OF USE | MKI67, PRKACA, PRKDC | TP53 47/4885HSD17B10 2613/4885MET 796/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.