Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.52 |
| ▸ | TAS1R3 | Q7RTX0 | 3/20 | 0.51 |
| ▸ | TAS1R1 | Q7RTX1 | 3/20 | 0.51 |
| ▸ | TAS1R2 | Q8TE23 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15564695 | 1.00 | HTT (0.55) | HTTALDH1A1KMT2AMEN1EPHX1 | |
| SCHEMBL18569491 | 1.00 | HTT (0.55) | HTTALDH1A1KMT2AMEN1EPHX1 | |
| SCHEMBL29857359 | 1.00 | HTT (0.55) | HTTALDH1A1KMT2AMEN1EPHX1 | |
| SCHEMBL31709770 | 1.00 | HTT (0.55) | HTTALDH1A1KMT2AMEN1EPHX1 | |
| Hydrochloric Acid SCHEMBL29892567 | 0.99 | HTT (0.54) | HTTALDH1A1KMT2AMEN1EPHX1 | |
| SCHEMBL16254377 | 0.90 | TAS1R3 (0.55) | HTTALDH1A1KMT2AMEN1EPHX1 | |
| SCHEMBL18173820 | 0.90 | TAS1R3 (0.55) | HTTALDH1A1KMT2AMEN1EPHX1 | |
| SCHEMBL22906909 | 0.90 | TAS1R3 (0.55) | HTTALDH1A1KMT2AMEN1EPHX1 | |
| SCHEMBL18173818 | 0.90 | TAS1R3 (0.55) | HTTALDH1A1KMT2AMEN1EPHX1 | |
| SCHEMBL16252351 | 0.90 | TAS1R3 (0.55) | HTTALDH1A1KMT2AMEN1EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2882740-B1 | IAP ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2017-03-01 | — | — | EP | disclosed |
| US-9453048-B2 | IAP antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-09-27 | — | — | US | disclosed |
| US-9453048-B2 | IAP antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-09-27 | — | — | US | disclosed |
| US-20150225452-A1 | IAP ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY | 2015-08-13 | — | — | US | disclosed |
| US-20150225452-A1 | IAP ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY | 2015-08-13 | — | — | US | disclosed |
| EP-2882740-A1 | IAP ANTAGONISTS | Bristol-Myers Squibb Company (US) | 2015-06-17 | — | — | EP | disclosed |
| WO-2014025759-A1 | IAP ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-02-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150225452-A1 | IAP ANTAGONISTS | XIAP, API5, BIRC5 | HTT 3265/4885ALDH1A1 3456/4885KMT2A 4432/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.