Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
| ▸ | QDPR | P09417 | 1/20 | 0.41 |
| ▸ | KMO | O15229 | 1/20 | 0.40 |
| ▸ | USP7 | Q93009 | 3/20 | 0.39 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.34 |
| ▸ | PLAT | P00750 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | PLG | P00747 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29878478 | 0.86 | KMO (0.46) | KMO | |
| SCHEMBL8167996 | 0.86 | KMO (0.46) | KMO | |
| SCHEMBL22121890 | 0.82 | KMO (0.51) | HRH4KMO | |
| Tert-Butyl Formate SCHEMBL27841239 | 0.82 | KMO (0.33) | HRH4QDPRKMOUSP7PLAT | |
| SCHEMBL23875068 | 0.78 | HRH4 (0.42) | HRH4KMOGABRA1KITCHRM4 | |
| SCHEMBL13934265 | 0.78 | HRH4 (0.42) | HRH4QDPRKMOUSP7SLC18A3 | |
| SCHEMBL25147466 | 0.78 | PIK3CD (0.41) | KMOCHRM4RPS6KA3 | |
| Hydrochloric Acid SCHEMBL4484147 | 0.76 | HRH4 (0.41) | HRH4KMOUSP7SLC18A3SIGMAR1 | |
| SCHEMBL14990759 | 0.74 | HTR2C (0.41) | HRH4PLAT | |
| SCHEMBL13294930 | 0.73 | MIF (0.46) | HRH4KMOSLC18A3SIGMAR1MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2303859-A2 | ARYL GPR119 AGONISTS AND USES THEREOF | Metabolex Inc. (US) | 2011-04-06 | — | — | EP | disclosed |
| WO-2010008739-A2 | ARYL GPR119 AGONISTS AND USES THEREOF | METABOLEX, INC. (US) | 2010-01-21 | — | — | WO | disclosed |