Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | PAK4 | O96013 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL27487574 | 0.98 | HTT (0.50) | KMT2AHTTDYRK1AIDO1MEN1 | |
| SCHEMBL1104634 | 0.83 | KMT2A (0.56) | KMT2AHTTDYRK1AIDO1MEN1 | |
| Bromide SCHEMBL725234 | 0.82 | KMT2A (0.54) | KMT2AHTTDYRK1AIDO1MEN1 | |
| Hydrochloric Acid SCHEMBL858442 | 0.82 | KMT2A (0.54) | KMT2AHTTDYRK1AIDO1MEN1 | |
| SCHEMBL29607382 | 0.79 | HTT (0.56) | KMT2AHTTDYRK1AIDO1MEN1 | |
| SCHEMBL14051242 | 0.79 | HTT (0.56) | KMT2AHTTDYRK1AIDO1MEN1 | |
| SCHEMBL23534521 | 0.78 | KMT2A (0.46) | KMT2AHTTDYRK1AIDO1MEN1 | |
| SCHEMBL68962 | 0.78 | KMT2A (0.54) | KMT2AHTTDYRK1AIDO1MEN1 | |
| SCHEMBL14493846 | 0.78 | KMT2A (0.54) | KMT2AHTTDYRK1AIDO1MEN1 | |
| SCHEMBL31746033 | 0.78 | HTT (0.54) | KMT2AHTTDYRK1AIDO1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2882738-B1 | NEW ANTIBACTERIAL COMPOUNDS | JANSSEN SCIENCES IRELAND UC (IE) | 2017-05-31 | — | — | EP | disclosed |
| EP-2882739-B1 | NEW ANTIBACTERIAL COMPOUNDS | JANSSEN SCIENCES IRELAND UC (IE) | 2017-05-03 | — | — | EP | disclosed |
| US-9315522-B2 | Antibacterial compounds | JANSSEN SCIENCES IRELAND UC (IE) | 2016-04-19 | — | — | US | disclosed |
| US-9296760-B2 | Antibacterial compounds | JANSSEN SCIENCES IRELAND UC (IE) | 2016-03-29 | — | — | US | disclosed |
| CN-104981466-A | novel antibacterial compounds | JANSSEN SCIENCES IRELAND UC | 2015-10-14 | — | — | CN | disclosed |
| US-20150225424-A1 | Antibacterial compounds | JANSSEN SCIENCES IRELAND UC (IE) | 2015-08-13 | — | — | US | disclosed |
| US-20150210719-A1 | ANTIBACTERIAL COMPOUNDS | JANSSEN SCIENCES IRELAND US (IE) | 2015-07-30 | — | — | US | disclosed |
| CN-104781250-A | New antibacterial compounds | JANSSEN SCIENCES IRELAND UC | 2015-07-15 | — | — | CN | disclosed |
| EP-2882738-A1 | NEW ANTIBACTERIAL COMPOUNDS | Janssen Sciences Ireland UC (IE) | 2015-06-17 | — | — | EP | disclosed |
| EP-2882739-A1 | NEW ANTIBACTERIAL COMPOUNDS | Janssen Sciences Ireland UC (IE) | 2015-06-17 | — | — | EP | disclosed |
| WO-2014023815-A1 | NEW ANTIBACTERIAL COMPOUNDS | JANSSEN R&D IRELAND (IE) | 2014-02-13 | — | — | WO | disclosed |
| WO-2014023814-A1 | NEW ANTIBACTERIAL COMPOUNDS | JANSSEN R&D IRELAND (IE) | 2014-02-13 | — | — | WO | disclosed |
| CN-102459249-A | Benzoxazepines based p13k/mt0r inhibitors against proliferative diseases | EXELIXIS INC | 2012-05-16 | — | — | CN | disclosed |
| CN-101415701-A | Heterocyclylacrylamide compounds as FABI inhibitors and antibacterial agents | AFFINIUM PHARM INC (CA) | 2009-04-22 | — | — | CN | disclosed |
| CN-1197860-C | FAB I inhibitors | SMITHKLINE BEECHAM CORP (CA) | 2005-04-20 | — | — | CN | disclosed |
| CN-1378542-A | Antigen binding fragment I inhibitors | SMITHKLINE BEECHAM CORP (US) | 2002-11-06 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150210719-A1 | ANTIBACTERIAL COMPOUNDS | FAR1, GAA, ECI1 | KMT2A 4351/4885HTT 4715/4885DYRK1A 4800/4885 |
| US-20150225424-A1 | Antibacterial compounds | FAR1, GAA, ECI1 | KMT2A 4351/4885HTT 4715/4885DYRK1A 4800/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.