Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 2/20 | 0.49 |
| ▸ | RXRB | P28702 | 1/20 | 0.49 |
| ▸ | RXRG | P48443 | 1/20 | 0.49 |
| ▸ | PTPN5 | P54829 | 2/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MDM4 | O15151 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TYR | P14679 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | CA5A | P35218 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6618721 | 0.90 | RXRA (0.45) | RXRARXRBRXRGPTPN5HDAC4 | |
| SCHEMBL5352034 | 0.84 | RXRA (0.62) | RXRARXRBRXRGPTPN5HDAC4 | |
| SCHEMBL598181 | 0.81 | RXRA (0.66) | RXRARXRBRXRGPTPN5HDAC4 | |
| Ethane SCHEMBL6908245 | 0.79 | RXRA (0.63) | RXRARXRBRXRGPTPN5HDAC4 | |
| SCHEMBL31122172 | 0.78 | HDAC4 (0.54) | RXRARXRBRXRGPTPN5HDAC4 | |
| SCHEMBL611807 | 0.77 | RXRA (0.67) | RXRARXRBRXRGPTPN5HDAC4 | |
| SCHEMBL29681626 | 0.77 | RXRA (0.67) | RXRARXRBRXRGPTPN5HDAC4 | |
| SCHEMBL8676319 | 0.77 | RXRA (0.56) | RXRARXRBRXRGPTPN5HDAC4 | |
| SCHEMBL29727265 | 0.76 | RXRA (0.65) | RXRARXRBRXRGPTPN5HDAC4 | |
| SCHEMBL9177215 | 0.76 | RXRA (0.50) | RXRARXRBRXRGPTPN5HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2882722-A1 | QUINOXALINE DERIVATIVES AS GPR6 MODULATORS | Envoy Therapeutics Inc. (US) | 2015-06-17 | — | — | EP | disclosed |
| WO-2014028479-A1 | QUINOXALINE DERIVATIVES AS GPR6 MODULATORS | ENVOY THERAPEUTICS, INC. (US) | 2014-02-20 | — | — | WO | disclosed |