Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT4 | P35916 | 14/20 | 0.65 |
| ▸ | KDR | P35968 | 2/20 | 0.51 |
| ▸ | JAK1 | P23458 | 4/20 | 0.41 |
| ▸ | JAK2 | O60674 | 3/20 | 0.40 |
| ▸ | TYK2 | P29597 | 3/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15567714 | 0.82 | FLT4 (0.67) | FLT4KDRJAK1JAK2TYK2 | |
| SCHEMBL17040085 | 0.79 | FLT4 (0.71) | FLT4KDR | |
| SCHEMBL15506709 | 0.79 | FLT4 (1.00) | FLT4KDR | |
| SCHEMBL15568521 | 0.78 | FLT4 (0.61) | FLT4KDR | |
| SCHEMBL15567595 | 0.74 | FLT4 (0.64) | FLT4KDR | |
| SCHEMBL15567622 | 0.73 | FLT4 (0.67) | FLT4KDR | |
| SCHEMBL28107724 | 0.73 | FLT4 (0.69) | FLT4KDR | |
| SCHEMBL28107721 | 0.72 | FLT4 (0.54) | FLT4KDR | |
| SCHEMBL15568298 | 0.71 | FLT4 (0.70) | FLT4KDR | |
| SCHEMBL28107726 | 0.71 | PTK2 (0.73) | FLT4KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2885291-A1 | VEGFR3 INHIBITORS | Cancer Therapeutics Crc Pty Limited (AU) | 2015-06-24 | — | — | EP | disclosed |
| WO-2014026243-A1 | VEGFR3 INHIBITORS | CANCER THERAPEUTICS CRC PTY LIMITED (AU) | 2014-02-20 | — | — | WO | disclosed |