Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 7/20 | 0.82 |
| ▸ | POLB | P06746 | 2/20 | 0.67 |
| ▸ | RAB9A | P51151 | 7/20 | 0.63 |
| ▸ | NPC1 | O15118 | 6/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 4/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21142712 | 0.80 | POLB (1.00) | TP53POLBRAB9ANPC1KMT2A | |
| SCHEMBL15082882 | 0.78 | MAPT (0.74) | TP53POLBRAB9ANPC1KMT2A | |
| SCHEMBL16756383 | 0.76 | KMT2A (0.62) | TP53POLBKMT2AMEN1TSHR | |
| SCHEMBL16756532 | 0.76 | KMT2A (0.62) | TP53POLBKMT2AMEN1TSHR | |
| SCHEMBL20715537 | 0.76 | TP53 (0.74) | TP53POLBKMT2AMEN1MAPT | |
| SCHEMBL16756323 | 0.75 | TP53 (0.60) | TP53POLBRAB9ANPC1KMT2A | |
| SCHEMBL16756571 | 0.75 | TP53 (0.60) | TP53POLBRAB9ANPC1KMT2A | |
| SCHEMBL16756266 | 0.75 | TP53 (0.60) | TP53POLBRAB9ANPC1KMT2A | |
| SCHEMBL6804801 | 0.71 | POLB (0.71) | TP53POLBRAB9ANPC1KMT2A | |
| SCHEMBL15063352 | 0.70 | TP53 (0.69) | TP53POLBRAB9ANPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014027053-A1 | BENZIMIDAZOLES FOR THE TREATMENT OF CANCER | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-02-20 | — | — | WO | disclosed |