Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.71 |
| ▸ | MEN1 | O00255 | 2/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.70 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.63 |
| ▸ | PPARA | Q07869 | 2/20 | 0.63 |
| ▸ | TP53 | P04637 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 6/20 | 0.48 |
| ▸ | RAB9A | P51151 | 6/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6800275 | 0.84 | RAB9A (0.69) | MEN1KMT2ATP53MAPTNPC1 | |
| SCHEMBL21142712 | 0.84 | POLB (1.00) | POLBMEN1KMT2AFFAR1PPARA | |
| SCHEMBL20088741 | 0.74 | POLB (0.71) | POLBMEN1KMT2ATP53RAB9A | |
| SCHEMBL6959910 | 0.72 | POLB (0.57) | POLBMEN1KMT2AFFAR1PPARA | |
| SCHEMBL15567435 | 0.71 | TP53 (0.82) | POLBMEN1KMT2ATP53MAPT | |
| SCHEMBL7721500 | 0.69 | POLB (0.63) | POLBMEN1KMT2ATP53MAPT | |
| SCHEMBL5520218 | 0.69 | PDE10A (0.66) | POLBMEN1KMT2A | |
| SCHEMBL9570011 | 0.69 | POLB (0.58) | POLBMEN1KMT2ATP53NPC1 | |
| SCHEMBL7274396 | 0.68 | POLB (0.55) | POLBMEN1KMT2AFFAR1PPARA | |
| SCHEMBL103328 | 0.68 | POLB (0.61) | POLBMEN1KMT2ATP53NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6770647-B2 | Bicyclic hydroxamates as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE) | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2004-08-03 | — | — | US | disclosed |