Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | NPY1R | P25929 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NPY2R | P49146 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30581236 | 0.77 | KDM4E (0.60) | SMN1; SMN2TP53MEN1KMT2AMAPT | |
| SCHEMBL29076126 | 0.77 | KDM4E (0.60) | SMN1; SMN2TP53MEN1KMT2AMAPT | |
| SCHEMBL6810630 | 0.76 | TLR8 (0.57) | SMN1; SMN2TP53MEN1KMT2AMAPT | |
| SCHEMBL20421688 | 0.75 | TNF (0.58) | SMN1; SMN2TP53MEN1KMT2AMAPT | |
| SCHEMBL21085204 | 0.74 | KDM4E (0.64) | SMN1; SMN2TP53MEN1KMT2AMAPT | |
| SCHEMBL1482899 | 0.73 | PRKACA (0.53) | TP53KDM4EHTTALDH1A1TSHR | |
| SCHEMBL10061948 | 0.72 | TP53 (0.45) | SMN1; SMN2TP53MEN1KMT2AMAPT | |
| SCHEMBL228955 | 0.72 | ALDH1A1 (0.56) | SMN1; SMN2TP53MEN1KMT2AMAPT | |
| SCHEMBL10061943 | 0.71 | KDM4E (0.70) | SMN1; SMN2TP53MEN1KMT2AMAPT | |
| SCHEMBL23673271 | 0.71 | KDM4E (0.44) | SMN1; SMN2TP53MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014027053-A1 | BENZIMIDAZOLES FOR THE TREATMENT OF CANCER | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-02-20 | — | — | WO | disclosed |