Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 12/20 | 0.48 |
| ▸ | PARP1 | P09874 | 9/20 | 0.44 |
| ▸ | TNKS2 | Q9H2K2 | 8/20 | 0.44 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.38 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.35 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.35 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15568327 | 0.81 | TNKS (0.62) | TNKSPARP1TNKS2PARP2PARP3 | |
| SCHEMBL15568640 | 0.81 | TNKS (0.57) | TNKSPARP1TNKS2PARP2PARP3 | |
| Hydrochloric Acid SCHEMBL15566906 | 0.80 | TNKS (0.56) | TNKSPARP1TNKS2PARP2PARP3 | |
| SCHEMBL15567513 | 0.76 | SMN1; SMN2 (0.61) | TNKSPARP1TNKS2SMN1; SMN2KDM4E | |
| SCHEMBL15287405 | 0.74 | TNKS (0.68) | TNKSPARP1TNKS2PARP2PARP3 | |
| SCHEMBL15568268 | 0.73 | TNKS (0.56) | TNKSPARP1TNKS2PARP2PARP3 | |
| SCHEMBL15568030 | 0.73 | TNKS (0.68) | TNKSPARP1TNKS2PARP2PARP3 | |
| SCHEMBL15567682 | 0.71 | TNKS (0.59) | TNKSPARP1TNKS2PARP2PARP3 | |
| SCHEMBL15569068 | 0.71 | TNKS (0.54) | TNKSPARP1TNKS2SMN1; SMN2KDM4E | |
| SCHEMBL16931442 | 0.70 | TNKS (0.53) | TNKSPARP1TNKS2SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2882714-B1 | (AZA-)ISOQUINOLINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2019-11-13 | — | — | EP | disclosed |
| US-9376433-B2 | (AZA-)isoquinolinone derivatives | MERCK PATENT GMBH (DE) | 2016-06-28 | — | — | US | disclosed |
| US-9376433-B2 | (AZA-)isoquinolinone derivatives | MERCK PATENT GMBH (DE) | 2016-06-28 | — | — | US | disclosed |
| US-20150210686-A1 | (AZA-)ISOQUINOLINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-07-30 | — | — | US | disclosed |
| US-20150210686-A1 | (AZA-)ISOQUINOLINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-07-30 | — | — | US | disclosed |
| EP-2882714-A2 | (AZA-)ISOQUINOLINONE DERIVATIVES | Merck Patent GmbH (DE) | 2015-06-17 | — | — | EP | disclosed |
| WO-2014023390-A2 | (AZA-)ISOQUINOLINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2014-02-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150210686-A1 | (AZA-)ISOQUINOLINONE DERIVATIVES | TANK, TNKS, TDP1 | TNKS 2/4885PARP1 39/4885TNKS2 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.