TANK — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL1546680	1.00	2/20
SCHEMBL1554482	1.00	2/20
SCHEMBL1546654	0.89	2/20
SCHEMBL1546914	0.89	2/20
SCHEMBL1547091	0.88	2/20
SCHEMBL1555902	0.88	2/20
SCHEMBL1547102	0.86	2/20
SCHEMBL1546563	0.85	2/20
SCHEMBL1546888	0.85	2/20
SCHEMBL1591314	0.85	2/20
SCHEMBL1547378	0.84	2/20
SCHEMBL1554516	0.84	2/20
SCHEMBL19061011	0.83	2/20
SCHEMBL1557375	0.83	2/20
SCHEMBL1546814	0.83	2/20
SCHEMBL1546915	0.82	2/20
SCHEMBL1547098	0.81	2/20
SCHEMBL1546622	0.81	2/20
SCHEMBL1546626	0.81	2/20
SCHEMBL12709130	0.81	2/20

Clinical trials — most relevant to TANK by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Clinical Evaluation of the Effect of Metformin in Sepsis	PHASE3	UNKNOWN
Assessment the Activity Value of Isotretinoin (13- Cis-Retinoic Acid ) in the Treatment of COVID-19 ( Isotretinoin in Treatment of COVID-19) (Randomized)	PHASE3	UNKNOWN
The Use of Inhaled Corticosteroids in the Treatment of Asthma is Children in the Emergency Room	PHASE2/PHASE3	COMPLETED
Effects of Gum Arabic on Metabolic Syndrome Parameters in Postmenopausal Women	PHASE2	COMPLETED
TNFSF11 Inhibition and Fertility: a Prospective Study	PHASE2	COMPLETED
Efficacy and Safety of Drug Combination Therapy of Isotretinoin and Some Antifungal Drugs as A Potential Aerosol Therapy for COVID-19 : An Innovative Therapeutic Approach COVID-19	PHASE2	UNKNOWN
Study of Axitinib in Patients With Neurofibromatosis Type 2 and Progressive Vestibular Schwannomas	PHASE2	COMPLETED
Efficacy of Amlexanox vs. Placebo in Type 2 Diabetic Patients	PHASE2	COMPLETED
Cilostazol in Parkinson's Disease	PHASE2	NOT_YET_RECRUITING
Simvastatin in Secondary Progressive Multiple Sclerosis	PHASE2	COMPLETED
A Phase I Study Of Thymoglobulin In Patients With Relapsed Or Refractory Multiple Myeloma	PHASE1	COMPLETED
Study of BCMA/CD70 CAR-T Therapy for Refractory cSLE	PHASE1	RECRUITING
Genetic Variation in TRAF3IP2 (rs13190932)	nan	RECRUITING
Novel Biomarkers in Inflammatory Bowel Disease	nan	COMPLETED
ADAR1 Expression Level in Rectal Cancer	nan	RECRUITING
IKBKB Gene Polymorphism (Single Nucleotide Polymorphism) (SNP) in Psoriatic and Psoriatic Arthritis Patients	nan	COMPLETED
RNA Cloning and Visualization in Human Atherosclerosis	nan	COMPLETED
Card14gene (rs34367357 ) Polymorphism in Egyptian Psoriatic and Psoriatic Arthritis Patient	nan	RECRUITING
MicroRNAs and Cytokines in Peri-Implantitis Tissue	nan	UNKNOWN
Role of NFKBIA and PTPN22 Genes Polymorphism in Acute Rejection Susceptibility After Living Donor Liver Transplantation in Egyptian Patients.	nan	COMPLETED
Deep Phenotyping of Cutaneous Lupus Erythematosus	nan	UNKNOWN
Mitigating Mitochondrial RNA Release During Aging to Control Inflammation and Senescence	nan	NOT_YET_RECRUITING
The Mechanisms and Significances of Synergistic Effects of Mycophenolic Acid and LPS on IL-1β Secretion by Mononuclear	nan	UNKNOWN
Exploration of the Activity of DNA Located Outside of Cellular Nucleus to Amplify Inflammation in Inflammatory Bowel Disease in Children Through Biological Pathway Cyclic GMP-AMP Synthase (cGAS) - Stimulator of Interferon Genes (STING)	nan	COMPLETED
Exploring Novel Biomarkers of ICU-AW in Mechanically Ventilated Children at the Molecular Level	nan	ENROLLING_BY_INVITATION
Blocking TNF to Potentiate the ICI-dependent Immune Awakening in Melanoma	nan	RECRUITING
Statin Therapy and COVID-19 Infection	nan	COMPLETED
Pigeon Peas (Cajanus Cajan) : a Natural Anti-inflammatory Facilitating Weight Loss in Obese Patients Returning to Sport?	nan	UNKNOWN
Immune Interactions in Severe Asthma	nan	COMPLETED
Role of Nox2 in CNI-induced Renal Fibrosis	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a TANK binder may also engage these)

Protein	Name	Similarity
P70347	—	1.000	P70347 →
Q86YC2	—	1.000	Q86YC2 →
Q3V089	—	1.000	Q3V089 →
Q9ULD2	—	1.000	Q9ULD2 →
Q6NZK5	—	0.999	Q6NZK5 →
A0JM80	—	0.998	A0JM80 →
Q6GNV6	—	0.998	Q6GNV6 →
Q2M2Z5	—	0.998	Q2M2Z5 →
E1BC15	—	0.998	E1BC15 →
Q49A88	—	0.998	Q49A88 →
Q60988	—	0.998	Q60988 →
A6H5Y1	—	0.997	A6H5Y1 →
Q6PG16	—	0.997	Q6PG16 →
Q6ZU52	—	0.997	Q6ZU52 →
Q569L8	—	0.997	Q569L8 →
Q8NCD3	—	0.997	Q8NCD3 →
Q6PDM4	—	0.997	Q6PDM4 →
P56716	—	0.997	P56716 →
Q66HB6	—	0.997	Q66HB6 →
A3KMW7	—	0.997	A3KMW7 →
A7E3D8	—	0.997	A7E3D8 →
Q5FBB7	—	0.997	Q5FBB7 →
Q62394	—	0.997	Q62394 →
A0A087WRU1	—	0.996	A0A087WRU1 →
A6NFA0	—	0.996	A6NFA0 →
Q8CDM4	—	0.996	Q8CDM4 →
Q6GQV1	—	0.996	Q6GQV1 →
Q86T90	—	0.996	Q86T90 →
Q5VWN6	—	0.996	Q5VWN6 →
Q5ZK13	—	0.996	Q5ZK13 →