Trifluoroacetic Acid

Trifluoroacetic Acid

SCHEMBL15568739

CN(C)c1ccc(CNC(=O)C2CCN(c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1.O=C(O)C(F)(F)F

nearest known ligand 0.59

Full drug profile on Sugi Atlas →

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
HRH1 P35367 16/20 0.59
CYP2D6 P10635 14/20 0.57
KCNH2 Q12809 7/20 0.57
CHRM1 P11229 8/20 0.56
MEN1 O00255 1/20 0.51
ALDH1A1 P00352 1/20 0.51
GAA P10253 1/20 0.51
MAPT P10636 1/20 0.51
HTT P42858 1/20 0.51
KMT2A Q03164 1/20 0.51
ADRA2A P08913 1/20 0.50
HTR2B P41595 1/20 0.50
PDE4D Q08499 1/20 0.50
PDE3A Q14432 1/20 0.50
HTR3A P46098 1/20 0.49
TP53 P04637 1/20 0.49
RXFP1 Q9HBX9 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoroacetic Acid SCHEMBL15568636 0.93 HRH1 (0.59) HRH1CYP2D6KCNH2CHRM1MEN1
Trifluoroacetic Acid SCHEMBL15569648 0.90 HRH1 (0.55) HRH1CYP2D6KCNH2CHRM1MEN1
Trifluoroacetic Acid SCHEMBL15568628 0.88 HRH1 (0.54) HRH1CYP2D6KCNH2CHRM1MEN1
Trifluoroacetic Acid SCHEMBL15567477 0.88 HRH1 (0.54) HRH1CYP2D6KCNH2CHRM1MEN1
Trifluoroacetic Acid SCHEMBL15569418 0.86 HRH1 (0.56) HRH1CYP2D6KCNH2CHRM1MEN1
Trifluoroacetic Acid SCHEMBL15568732 0.86 LMNA (0.57) HRH1CYP2D6KCNH2CHRM1MEN1
Trifluoroacetic Acid SCHEMBL15568655 0.85 KMT2A (0.56) HRH1CYP2D6KCNH2CHRM1MEN1
Trifluoroacetic Acid SCHEMBL15567399 0.85 LMNA (0.56) HRH1CYP2D6KCNH2CHRM1MEN1
Trifluoroacetic Acid SCHEMBL15568005 0.84 HRH1 (0.58) HRH1CYP2D6KCNH2CHRM1MEN1
Trifluoroacetic Acid SCHEMBL15567432 0.84 HRH1 (0.53) HRH1CYP2D6KCNH2CHRM1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2014027053-A1 BENZIMIDAZOLES FOR THE TREATMENT OF CANCER MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) 2014-02-20 WO claimed
WO-2014027053-A1 BENZIMIDAZOLES FOR THE TREATMENT OF CANCER MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) 2014-02-20 WO disclosed