Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP2 | P42575 | 1/20 | 0.74 |
| ▸ | NAAA | Q02083 | 1/20 | 0.58 |
| ▸ | FAAH | O00519 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 4/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28422719 | 1.00 | CASP2 (0.74) | CASP2NAAAFAAHMEN1KMT2A | |
| SCHEMBL1556009 | 0.98 | CASP2 (0.70) | CASP2NAAAFAAHMEN1KMT2A | |
| SCHEMBL1556215 | 0.92 | CASP2 (0.67) | CASP2NAAAFAAHMEN1KMT2A | |
| SCHEMBL28422794 | 0.90 | CASP2 (0.66) | CASP2NAAAFAAHDNM1EPHX1 | |
| SCHEMBL14199967 | 0.89 | CASP2 (0.91) | CASP2NAAAFAAHMEN1KMT2A | |
| SCHEMBL10443771 | 0.89 | CASP2 (0.69) | CASP2NAAAFAAHDNM1EPHX1 | |
| SCHEMBL5535283 | 0.89 | CASP2 (0.69) | CASP2NAAAFAAHDNM1EPHX1 | |
| SCHEMBL10895513 | 0.89 | CASP2 (0.69) | CASP2NAAAFAAHDNM1EPHX1 | |
| SCHEMBL5541786 | 0.89 | CASP2 (0.69) | CASP2NAAAFAAHDNM1EPHX1 | |
| SCHEMBL7286083 | 0.89 | CASP2 (0.69) | CASP2NAAAFAAHDNM1EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120301552-A1 | CaSR Antagonist | JAPAN TOBACCO INC. (JP) | 2012-11-29 | — | — | US | disclosed |
| EP-2308828-A2 | CaSR antagonist | Japan Tobacco Inc. (JP) | 2011-04-13 | — | — | EP | disclosed |
| EP-2189439-A2 | CaSR antagonist | Japan Tobacco, Inc. (JP) | 2010-05-26 | — | — | EP | disclosed |
| US-20090326058-A1 | CaSR Antagonist | JAPAN TOBACCO INC. (JP) | 2009-12-31 | — | — | US | disclosed |
| EP-1619180-B1 | CaSR ANTAGONIST | JAPAN TOBACCO INC (JP) | 2009-12-16 | — | — | EP | disclosed |
| US-20080255042-A1 | CaSR Antagonist | JAPAN TOBACCO INC. (JP) | 2008-10-16 | — | — | US | disclosed |
| US-7304174-B2 | CaSR antagonist | JAPAN TOBACCO INC. (JP) | 2007-12-04 | — | — | US | disclosed |
| US-7285572-B2 | CaSR antagonist | JAPAN TOBACCO INC. (JP) | 2007-10-23 | — | — | US | disclosed |
| US-20060135572-A1 | CaSR antagonist | JAPAN TOBACCO INC. (JP) | 2006-06-22 | — | — | US | disclosed |
| EP-1630157-A1 | CaSR ANTAGONIST | JAPAN TOBACCO INC. (JP) | 2006-03-01 | — | — | EP | disclosed |
| EP-1619180-A1 | CaSR ANTAGONIST | JAPAN TOBACCO INC. (JP) | 2006-01-25 | — | — | EP | disclosed |
| US-20050032796-A1 | Compounds as for example, 2'-[1-[(2R)-3-[[1-(3-fluoro-4-methylphenyl)-2-methylpropan-2-yl]amino]-2-hydroxypropoxy]ethyl]-3-methylbiphenyl-4-carboxylic acid, having a calcium-sensing receptor antagonistic action; therapeutic drug for osteoporosis | JAPAN TOBACCO INC. | 2005-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090326058-A1 | CaSR Antagonist | CASR, CALCR, CALCRL | CASP2 1948/4885NAAA 2807/4885FAAH 3669/4885 |
| US-20060135572-A1 | CaSR antagonist | CASR, CALCR, CALCRL | CASP2 2108/4885NAAA 2558/4885FAAH 3179/4885 |
| US-20120301552-A1 | CaSR Antagonist | CASR, CALCR, CALCRL | CASP2 1948/4885NAAA 2807/4885FAAH 3669/4885 |
| US-20080255042-A1 | CaSR Antagonist | CASR, CALCR, CALCRL | CASP2 1948/4885NAAA 2807/4885FAAH 3669/4885 |
| US-20050032796-A1 | Compounds as for example, 2'-[1-[(2R)-3-[[1-(3-fluoro-4-methylphenyl)-2-methylpropan-2-yl]amino]-2-hydroxypropoxy]ethyl]-3-methylbiphenyl-4-carboxylic acid, having a calcium-sensing receptor antagonistic action; therapeutic drug for osteoporosis | CASR, CALCR, GRK2 | CASP2 2936/4885NAAA 3922/4885FAAH 3392/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.