CASP2 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Spermine (SCHEMBL14965)	1.00	2/20
SCHEMBL20976	1.00	2/20
Spermine (SCHEMBL288720)	1.00	2/20
Spermidine (SCHEMBL15618)	0.93	2/20
SCHEMBL222228	0.93	2/20
Spermine (SCHEMBL288605)	0.93	2/20
Spermidine (SCHEMBL288987)	0.93	2/20
Spermine (SCHEMBL348192)	0.93	2/20
Spermine (SCHEMBL348194)	0.93	2/20
Spermine (SCHEMBL431884)	0.93	2/20
SCHEMBL333029	0.87	2/20
Spermidine (SCHEMBL343877)	0.87	2/20
SCHEMBL138047	0.86	2/20
Thermine (SCHEMBL181589)	0.86	2/20
SCHEMBL322518	0.86	2/20
SCHEMBL323273	0.86	2/20
SCHEMBL448382	0.86	2/20
SCHEMBL42927	0.80	2/20
SCHEMBL264012	0.80	2/20
SCHEMBL322618	0.80	2/20

Clinical trials — most relevant to CASP2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Can Vitamin D Reduce Heart Muscle Damage After Bypass Surgery?	PHASE4	COMPLETED
Dexmedetomidine to Prevent Hepatic Ischemia-reperfusion Injury-induced Glycocalyx Degradation and Early Allograft Dysfunction in Liver Transplantation	PHASE4	ACTIVE_NOT_RECRUITING
Clinical Study Evaluating the Anticancer Effect of Pentoxiphylline in Patients With Metastatic Colorectal Cancer	PHASE4	UNKNOWN
Lithium for Prevention of Cognitive Declining in Mood Illnesses	PHASE4	NOT_YET_RECRUITING
Strategies to Reduce Organic Muscle Atrophy in the Intensive Care Unit	PHASE2/PHASE3	WITHDRAWN
Minocycline for the Treatment of Early-Phase Schizophrenia	PHASE3	COMPLETED
Disulfiram in Rheumatoid Arthritis	PHASE2	NOT_YET_RECRUITING
Esomeprazole Magnesium With or Without Aspirin in Preventing Esophageal Cancer in Patients With Barrett Esophagus	PHASE2	COMPLETED
Atorvastatin Calcium, Oligofructose-Enriched Inulin, or Sulindac in Preventing Cancer in Patients at Increased Risk of Developing Colorectal Neoplasia	PHASE2	COMPLETED
Effect of Modified Citrus Pectin on PSA Kinetics in Biochemical Relapsed PC With Serial Increases in PSA	PHASE2	COMPLETED
Safety, Tolerability, and Treatment Effect of Belnacasan in Patients With COVID-19	PHASE2	COMPLETED
Safety and Efficacy Study of a Caspase Inhibitor in Patients Undergoing Liver Transplantation	PHASE2	COMPLETED
Phase II Study of Sorafenib + Carboplatin and Docetaxel in First Line Treatment of Stage IIIB/IV NSCLC	PHASE2	COMPLETED
Influence of Morphine or Ketamine or Saline Applied During In-hospital Cardiopulmonary Resuscitation on Early Survival	PHASE1	UNKNOWN
A Phase I Trial of T Cells Expressing an Anti-GD2 Chimeric Antigen Receptor in Children and Young Adults With GD2+ Solid Tumors	PHASE1	COMPLETED
Circulating Markers for Ischemic Heart Disease	nan	RECRUITING
Apoptosis Markers in Aggressive Periodontitis	nan	COMPLETED
Circulating Markers That Underlie the Transition From Compensated Hypertrophy to Heart Failure	nan	RECRUITING
Impact of CASP3 Gene in Chemoresistance	nan	NOT_YET_RECRUITING
New Signaling Pathway Targeting Systemic Lupus Erythematosus	nan	UNKNOWN
Serum Caspase 3, Annexin a2 and Soluble Fas Levels and Endometriosis	nan	COMPLETED
Role of Serum ADAM 17 (A Disintegrin And Metalloprotease 17) and Caspase 3 in Patients With Chronic Kidney Disease	nan	NOT_YET_RECRUITING
Analysis of the Variation in Caspase-8 Availability and Cleavage in Oral Squamous Cell Carcinoma	nan	UNKNOWN
Evaluation of Serum Gasdermin D Level As a Potential Biomarker of Disease Activity in Vitiligo Patients	nan	UNKNOWN
Effect of Periodontal Treatment on Inflammasome Proteins in Periodontal Diseases	nan	UNKNOWN
Functional Pharmacogenomics of Childhood Acute Lymphoblastic Leukemia in Taiwan	nan	UNKNOWN
Patient-Derived Organoids to Functionally Characterize Chemotherapy Resistance in Breast Cancer	nan	NOT_YET_RECRUITING
The Effect of Vitamin E-coated Polysulfone Membrane on Oxidative Stress, Inflammation and Monocytes in Critically Ill Patients in CRRT	nan	UNKNOWN
High Dose Omega-3 Fatty Acids in the Treatment of Sport Related Concussions	nan	COMPLETED
The Mechanisms and Significances of Synergistic Effects of Mycophenolic Acid and LPS on IL-1β Secretion by Mononuclear	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a CASP2 binder may also engage these)

Protein	Name	Similarity
P55215	—	1.000	P55215 →
P29594	—	1.000	P29594 →
Q98943	—	0.991	Q98943 →
O35732	—	0.984	O35732 →
Q9JHX4	—	0.979	Q9JHX4 →
O15519	—	0.971	O15519 →
CASP8	Caspase-8	0.970	landscape →
O89110	—	0.970	O89110 →
CASP10	Caspase-10	0.969	landscape →
Q9R144	—	0.968	Q9R144 →
Q8C3Q9	—	0.967	Q8C3Q9 →
CASP9	Caspase-9	0.966	landscape →
Q5RD56	—	0.964	Q5RD56 →
MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.963	landscape →
Q2TBA3	—	0.961	Q2TBA3 →
Q8K3Z0	—	0.961	Q8K3Z0 →
Q8BHB0	—	0.960	Q8BHB0 →
Q6AYG3	—	0.959	Q6AYG3 →
Q6E804	—	0.958	Q6E804 →
Q53B88	—	0.958	Q53B88 →
PARP4	Protein mono-ADP-ribosyltransferase PARP4	0.958	landscape →
E9PYK3	—	0.958	E9PYK3 →
O70583	—	0.958	O70583 →
CASP14	Caspase-14	0.958	landscape →
PRUNE1	Exopolyphosphatase PRUNE1	0.958	landscape →
G1T469	—	0.957	G1T469 →
NOD1	Nucleotide-binding oligomerization domain-containing protein 1	0.957	landscape →
P79942	—	0.957	P79942 →
P47823	—	0.957	P47823 →
O35710	—	0.957	O35710 →