Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 5/20 | 0.43 |
| ▸ | CES2 | O00748 | 3/20 | 0.43 |
| ▸ | ALB | P02768 | 1/20 | 0.41 |
| ▸ | KCNN4 | O15554 | 2/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | TTR | P02766 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CHIT1 | Q13231 | 1/20 | 0.37 |
| ▸ | G6PD | P11413 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | CASP6 | P55212 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL15569991 | 0.87 | KDM4E (0.41) | CES1CES2 | |
| Trifluoroacetic Acid SCHEMBL3596920 | 0.82 | CES1 (0.44) | CES1CES2ALBKCNN4BCHE | |
| Trifluoroacetic Acid SCHEMBL15568889 | 0.79 | CES1 (0.50) | CES1CES2ALBKCNN4L3MBTL1 | |
| SCHEMBL113475 | 0.78 | — | — | |
| SCHEMBL7008611 | 0.78 | CES1 (0.44) | CES1CES2ALBBCHEHDAC1 | |
| Urea SCHEMBL28869223 | 0.77 | CES2 (0.46) | CES1CES2ALBKCNN4BCHE | |
| Trifluoroacetic Acid SCHEMBL30333105 | 0.76 | CA1 (0.42) | CES1CES2L3MBTL1 | |
| Hydrochloric Acid SCHEMBL7423355 | 0.75 | CES2 (0.39) | CES1CES2BCHEHDAC1 | |
| Methane SCHEMBL1703075 | 0.75 | SMN1; SMN2 (0.43) | CES1CES2BCHEHDAC1HDAC6 | |
| Bromide SCHEMBL29216576 | 0.75 | CES2 (0.39) | CES1CES2BCHEHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104540806-B | Azaheterocycles as BIR2 and/or BIR3 inhibitors | 霍夫曼-拉罗奇有限公司 | 2017-05-03 | — | — | CN | disclosed |
| US-9422332-B2 | Azaheterocycles as BIR2 and/or BIR3 inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2016-08-23 | — | — | US | disclosed |
| US-20150210739-A1 | AZAHETEROCYCLES AS BIR2 AND/OR BIR3 INHIBITORS | HOFFMANN-LA ROCHE INC. | 2015-07-30 | — | — | US | disclosed |
| EP-2885275-A1 | AZAHETEROCYCLES AS BIR2 AND/OR BIR3 INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2015-06-24 | — | — | EP | disclosed |
| CN-104540806-A | Azaheterocycles as BIR2 and/or BIR3 inhibitors | HOFFMANN LA ROCHE | 2015-04-22 | — | — | CN | disclosed |
| WO-2014026882-A1 | AZAHETEROCYCLES AS BIR2 AND/OR BIR3 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2014-02-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150210739-A1 | AZAHETEROCYCLES AS BIR2 AND/OR BIR3 INHIBITORS | BIRC3, BIRC5, BIRC2 | CES1 3902/4885CES2 4095/4885ALB 4632/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.