Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.46 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.46 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.43 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.43 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | PRCP | P42785 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.43 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2775554 | 0.74 | DPP4 (0.46) | DPP4AKR1C1GRIN2DGRIN3BCYP2B6 | |
| SCHEMBL869351 | 0.72 | DPP4 (0.50) | DPP4AKR1C1GRIN2DGRIN3BCYP2B6 | |
| SCHEMBL827795 | 0.72 | OPRM1 (0.61) | DPP4AKR1C1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL723224 | 0.72 | GRIN2D (0.47) | DPP4AKR1C1GRIN2DGRIN3BCYP2B6 | |
| SCHEMBL24157288 | 0.70 | ESR1 (0.58) | GRIN2DGRIN3BCYP2B6SLC6A2SLC6A4 | |
| SCHEMBL30877902 | 0.70 | ESR1 (0.58) | GRIN2DGRIN3BCYP2B6SLC6A2SLC6A4 | |
| SCHEMBL30877914 | 0.70 | ESR1 (0.58) | GRIN2DGRIN3BCYP2B6SLC6A2SLC6A4 | |
| SCHEMBL30078304 | 0.70 | ESR1 (0.58) | GRIN2DGRIN3BCYP2B6SLC6A2SLC6A4 | |
| SCHEMBL868923 | 0.70 | SLC6A4 (0.50) | DPP4AKR1C1GRIN2DGRIN3BCYP2B6 | |
| SCHEMBL28378542 | 0.70 | ESR1 (0.58) | GRIN2DGRIN3BCYP2B6SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2885289-A1 | DIHYDROXYPYRIMIDINE CARBONIC ACID DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE | Savira Pharmaceuticals GmbH (AT) | 2015-06-24 | — | — | EP | disclosed |
| WO-2014023691-A1 | DIHYDROXYPYRIMIDINE CARBONIC ACID DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE | SAVIRA PHARMACEUTICALS GMBH (AT) | 2014-02-13 | — | — | WO | disclosed |