Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 6/20 | 0.56 |
| ▸ | JAK3 | P52333 | 5/20 | 0.35 |
| ▸ | BTK | Q06187 | 5/20 | 0.35 |
| ▸ | LCK | P06239 | 4/20 | 0.35 |
| ▸ | AURKA | O14965 | 3/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.31 |
| ▸ | GABRP | O00591 | 1/20 | 0.30 |
| ▸ | GABRD | O14764 | 1/20 | 0.30 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.30 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.30 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.30 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.30 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.30 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.30 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.30 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.30 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.30 |
| ▸ | GABRE | P78334 | 1/20 | 0.30 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15569830 | 0.79 | SYK (0.45) | SYKJAK3 | |
| SCHEMBL15569920 | 0.76 | SYK (0.74) | SYKJAK3BTKLCKAURKA | |
| SCHEMBL15569838 | 0.71 | SYK (1.00) | SYK | |
| SCHEMBL15570000 | 0.68 | SYK (1.00) | SYK | |
| Hydrochloric Acid SCHEMBL27979068 | 0.64 | BTK (0.40) | SYKJAK3BTKLCKAURKA | |
| SCHEMBL14976555 | 0.64 | SYK (0.58) | SYK | |
| SCHEMBL14976556 | 0.64 | SYK (0.58) | SYK | |
| Hydrochloric Acid SCHEMBL27979028 | 0.63 | BTK (0.44) | JAK3BTKLCKAURKAGABRP | |
| SCHEMBL9108450 | 0.63 | BTK (0.37) | SYKJAK3BTKLCKIRAK4 | |
| SCHEMBL5027979 | 0.63 | BTK (0.37) | SYKJAK3BTKLCKIRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2888262-A1 | PYRROLO[2,3-B]PYRAZINES AS SYK INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2015-07-01 | — | — | EP | disclosed |
| WO-2014029732-A1 | PYRROLO[2,3-B]PYRAZINES AS SYK INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2014-02-27 | — | — | WO | disclosed |