Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 13/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 4/20 | 0.34 |
| ▸ | XDH | P47989 | 1/20 | 0.32 |
| ▸ | NNMT | P40261 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 2/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15569702 | 0.79 | SYK (0.56) | SYKJAK3 | |
| SCHEMBL15569828 | 0.70 | SYK (0.67) | SYKJAK3 | |
| Hydrochloric Acid SCHEMBL27979028 | 0.65 | BTK (0.44) | JAK3JAK2 | |
| Hydrochloric Acid SCHEMBL27979068 | 0.65 | BTK (0.40) | SYKJAK3 | |
| SCHEMBL30502905 | 0.65 | NNMT (0.40) | SYKJAK3NNMTJAK1JAK2 | |
| SCHEMBL15569933 | 0.64 | SYK (0.72) | SYKJAK3JAK2 | |
| SCHEMBL27491593 | 0.64 | GABRP (0.55) | NNMT | |
| SCHEMBL30945485 | 0.63 | HSD11B1 (0.45) | SYKHSD11B1JAK3NNMTJAK1 | |
| SCHEMBL15569686 | 0.62 | SYK (1.00) | SYK | |
| SCHEMBL27815355 | 0.62 | GABRP (0.42) | XDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2888262-A1 | PYRROLO[2,3-B]PYRAZINES AS SYK INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2015-07-01 | — | — | EP | disclosed |
| WO-2014029732-A1 | PYRROLO[2,3-B]PYRAZINES AS SYK INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2014-02-27 | — | — | WO | disclosed |