Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.37 |
| ▸ | MDM4 | O15151 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15569741 | 1.00 | CASP3 (0.40) | CASP3KMT2AMDM2MDM4TP53 | |
| SCHEMBL1956272 | 0.93 | CASP3 (0.46) | CASP3KMT2AMDM2MDM4TP53 | |
| SCHEMBL1956271 | 0.93 | CASP3 (0.46) | CASP3KMT2AMDM2MDM4TP53 | |
| SCHEMBL119715 | 0.80 | CASP3 (0.55) | CASP3KMT2AMDM2MDM4TP53 | |
| SCHEMBL14265316 | 0.80 | CASP3 (0.55) | CASP3KMT2AMDM2MDM4TP53 | |
| SCHEMBL29402145 | 0.80 | CASP3 (0.55) | CASP3KMT2AMDM2MDM4TP53 | |
| SCHEMBL1955384 | 0.79 | CASP3 (0.54) | CASP3KMT2AMDM4TP53 | |
| SCHEMBL2948034 | 0.79 | CASP3 (0.54) | CASP3KMT2AMDM4TP53 | |
| SCHEMBL29424533 | 0.79 | CASP3 (0.54) | CASP3KMT2AMDM4TP53 | |
| SCHEMBL29400295 | 0.78 | CASP3 (0.48) | CASP3KMT2AMDM2MDM4TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2882439-B1 | APOPTOSIS-INDUCING AGENTS | ABBVIE INC (US) | 2018-04-11 | — | — | EP | disclosed |
| EP-2882439-A1 | APOPTOSIS-INDUCING AGENTS | AbbVie Inc. (US) | 2015-06-17 | — | — | EP | disclosed |
| WO-2014028381-A1 | APOPTOSIS-INDUCING AGENTS | ABBVIE INC. (US) | 2014-02-20 | — | — | WO | disclosed |