Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 11/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | TTK | P33981 | 1/20 | 0.32 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14795161 | 0.82 | DGAT1 (0.47) | DGAT1KLKB1MAPT | |
| SCHEMBL2346604 | 0.80 | DGAT1 (0.36) | DGAT1NPC1KLKB1MAPT | |
| SCHEMBL12402542 | 0.77 | DGAT1 (0.36) | DGAT1KLKB1MAPT | |
| SCHEMBL650307 | 0.77 | DGAT1 (0.42) | DGAT1KLKB1MAPT | |
| SCHEMBL15570073 | 0.77 | DGAT1 (0.37) | DGAT1MAPT | |
| SCHEMBL12145882 | 0.76 | KLKB1 (0.40) | DGAT1KLKB1MAPT | |
| SCHEMBL1370138 | 0.76 | DGAT1 (0.38) | DGAT1 | |
| SCHEMBL3428480 | 0.76 | DGAT1 (0.36) | DGAT1KLKB1MAPT | |
| SCHEMBL1352880 | 0.76 | DGAT1 (0.42) | DGAT1NPC1KLKB1MAPT | |
| SCHEMBL14738023 | 0.76 | DGAT1 (0.42) | DGAT1NPC1KLKB1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2888262-A1 | PYRROLO[2,3-B]PYRAZINES AS SYK INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2015-07-01 | — | — | EP | disclosed |
| WO-2014029732-A1 | PYRROLO[2,3-B]PYRAZINES AS SYK INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2014-02-27 | — | — | WO | disclosed |