Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 5/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CNR2 | P34972 | 6/20 | 0.32 |
| ▸ | CNR1 | P21554 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28132633 | 0.85 | PDE4A (0.36) | DGAT1MAPTCNR2CNR1 | |
| SCHEMBL28006120 | 0.85 | DGAT1 (0.39) | DGAT1MAPTLMNATHRBSYK | |
| SCHEMBL15570073 | 0.84 | DGAT1 (0.37) | DGAT1MAPTLMNATHRBSYK | |
| SCHEMBL13858243 | 0.84 | DGAT1 (0.40) | DGAT1MAPTLMNATHRBSYK | |
| SCHEMBL28133563 | 0.83 | KLKB1 (0.37) | DGAT1MAPTKLKB1NPC1 | |
| SCHEMBL28813695 | 0.81 | DGAT1 (0.34) | DGAT1 | |
| SCHEMBL15569796 | 0.80 | DGAT1 (0.36) | DGAT1MAPTLMNATHRBSMN1; SMN2 | |
| SCHEMBL15569034 | 0.79 | DGAT1 (0.40) | DGAT1MAPTCNR1 | |
| SCHEMBL16968270 | 0.79 | SYK (0.52) | DGAT1SYK | |
| SCHEMBL16968276 | 0.79 | SYK (0.52) | DGAT1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104024258-B | Pyrrolopyrazine kinase inhibitors | 霍夫曼-拉罗奇有限公司 | 2017-02-15 | — | — | CN | disclosed |
| EP-2888262-A1 | PYRROLO[2,3-B]PYRAZINES AS SYK INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2015-07-01 | — | — | EP | disclosed |
| CN-104507945-A | Pyrrolo[2,3-B]pyrazines as SYK inhibitors | HOFFMANN LA ROCHE | 2015-04-08 | — | — | CN | disclosed |
| WO-2014029732-A1 | PYRROLO[2,3-B]PYRAZINES AS SYK INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2014-02-27 | — | — | WO | disclosed |