Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 1.00 |
| ▸ | MAPT | P10636 | 8/20 | 1.00 |
| ▸ | CUL4A | Q13619 | 6/20 | 1.00 |
| ▸ | MEN1 | O00255 | 6/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 6/20 | 1.00 |
| ▸ | HPGD | P15428 | 6/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 1.00 |
| ▸ | MAPK10 | P53779 | 1/20 | 1.00 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 1.00 |
| ▸ | GAA | P10253 | 3/20 | 0.67 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.64 |
| ▸ | PKM | P14618 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.54 |
| ▸ | BLM | P54132 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | PPARG | P37231 | 2/20 | 0.54 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15571179 | 0.97 | CUL4A (1.00) | ALDH1A1MAPTCUL4AMEN1KMT2A | |
| SCHEMBL18719837 | 0.81 | PDE9A (0.73) | ALDH1A1MAPTCUL4AMEN1KMT2A | |
| SCHEMBL15571850 | 0.81 | CUL4A (1.00) | ALDH1A1MAPTCUL4AMEN1KMT2A | |
| SCHEMBL24232982 | 0.70 | HPGD (0.56) | ALDH1A1MAPTCUL4AMEN1KMT2A | |
| SCHEMBL6253844 | 0.70 | KDM4E (1.00) | ALDH1A1MEN1KMT2AHPGDKDM4E | |
| SCHEMBL17747485 | 0.69 | ALDH1A1 (0.76) | ALDH1A1MAPTCUL4AMEN1KMT2A | |
| SCHEMBL15570369 | 0.68 | ALDH1A1 (1.00) | ALDH1A1MAPTCUL4AMEN1KMT2A | |
| SCHEMBL15572315 | 0.68 | CUL4A (1.00) | ALDH1A1MAPTCUL4AMEN1KMT2A | |
| SCHEMBL1539839 | 0.68 | CUL4A (0.73) | ALDH1A1MAPTCUL4AMEN1KMT2A | |
| SCHEMBL6253678 | 0.68 | KDM4E (0.95) | ALDH1A1MEN1KMT2AHPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150196546-A1 | INHIBITORS OF CRL4 UBIQUITIN LIGASE AND USES THEREOF | CORNELL UNIVERSITY | 2015-07-16 | — | — | US | claimed |
| EP-2887940-A2 | INHIBITORS OF CRL4 UBIQUITIN LIGASE AND USES THEREOF | Cornell University (US) | 2015-07-01 | — | — | EP | claimed |
| WO-2014031759-A2 | INHIBITORS OF CRL4 UBIQUITIN LIGASE AND USES THEREOF | CORNELL UNIVERSITY (US) | 2014-02-27 | — | — | WO | claimed |
| US-10617683-B2 | Inhibitors of CRL4 ubiquitin ligase and uses thereof | CORNELL UNIVERSITY (US) | 2020-04-14 | — | — | US | disclosed |
| EP-2887940-B1 | INHIBITORS OF CRL4 UBIQUITIN LIGASE AND USES THEREOF | UNIV CORNELL (US) | 2019-06-05 | — | — | EP | disclosed |
| US-20150196546-A1 | INHIBITORS OF CRL4 UBIQUITIN LIGASE AND USES THEREOF | CORNELL UNIVERSITY | 2015-07-16 | — | — | US | disclosed |
| EP-2887940-A2 | INHIBITORS OF CRL4 UBIQUITIN LIGASE AND USES THEREOF | Cornell University (US) | 2015-07-01 | — | — | EP | disclosed |
| WO-2014031759-A2 | INHIBITORS OF CRL4 UBIQUITIN LIGASE AND USES THEREOF | CORNELL UNIVERSITY (US) | 2014-02-27 | — | — | WO | disclosed |