Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | CACNA1B | Q00975 | 8/20 | 0.51 |
| ▸ | CACNA1H | O95180 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16990731 | 0.88 | CACNA1B (0.48) | POLBCACNA1BCACNA1HKMT2AMEN1 | |
| SCHEMBL13603469 | 0.87 | DDR2 (0.52) | POLBCACNA1BCACNA1HKMT2AMEN1 | |
| SCHEMBL15575211 | 0.83 | ALDH1A1 (0.66) | POLBKMT2AMEN1GAAALDH1A1 | |
| SCHEMBL15575316 | 0.79 | NAMPT (0.61) | KMT2AMEN1GAAALDH1A1NAMPT | |
| SCHEMBL15574706 | 0.78 | ALDH1A1 (0.57) | POLBKMT2AMEN1GAAALDH1A1 | |
| SCHEMBL15574561 | 0.77 | NAMPT (0.61) | POLBKMT2AMEN1ALDH1A1NAMPT | |
| SCHEMBL15574732 | 0.77 | ALDH1A1 (0.55) | KMT2AMEN1ALDH1A1NAMPTTRPV1 | |
| SCHEMBL16990677 | 0.76 | DDR2 (0.74) | ALDH1A1NAMPTROCK2CYP3A4CYP2D6 | |
| SCHEMBL16990708 | 0.76 | RAF1 (0.58) | ALDH1A1TRPV1 | |
| SCHEMBL16990698 | 0.75 | NAMPT (0.61) | ALDH1A1NAMPTROCK2CYP3A4ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2890380-A2 | DDR2 INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS | Merck Patent GmbH (DE) | 2015-07-08 | — | — | EP | disclosed |
| WO-2014032755-A2 | DDR2 INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS | MERCK PATENT GMBH (DE) | 2014-03-06 | — | — | WO | disclosed |