Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 1.00 |
| ▸ | MAPT | P10636 | 10/20 | 1.00 |
| ▸ | HPGD | P15428 | 9/20 | 1.00 |
| ▸ | MEN1 | O00255 | 9/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 9/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 8/20 | 1.00 |
| ▸ | DUSP3 | P51452 | 7/20 | 1.00 |
| ▸ | LMNA | P02545 | 7/20 | 1.00 |
| ▸ | POLB | P06746 | 5/20 | 1.00 |
| ▸ | HTT | P42858 | 4/20 | 1.00 |
| ▸ | ESR1 | P03372 | 1/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 9/20 | 0.84 |
| ▸ | TP53 | P04637 | 8/20 | 0.84 |
| ▸ | PTPN7 | P35236 | 2/20 | 0.84 |
| ▸ | TSHR | P16473 | 1/20 | 0.84 |
| ▸ | BLM | P54132 | 1/20 | 0.84 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.84 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.84 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30065644 | 1.00 | ALDH1A1 (1.00) | ALDH1A1KDM4EMAPTHPGDMEN1 | |
| Hydrochloric Acid SCHEMBL29921361 | 0.99 | ALDH1A1 (0.98) | ALDH1A1KDM4EMAPTHPGDMEN1 | |
| SCHEMBL15617100 | 0.91 | ALDH1A1 (0.84) | ALDH1A1KDM4EMAPTHPGDMEN1 | |
| SCHEMBL15575996 | 0.91 | ALDH1A1 (1.00) | ALDH1A1KDM4EMAPTHPGDMEN1 | |
| SCHEMBL15617091 | 0.90 | ALDH1A1 (0.82) | ALDH1A1KDM4EMAPTHPGDMEN1 | |
| SCHEMBL20660703 | 0.90 | ALDH1A1 (0.82) | ALDH1A1KDM4EMAPTHPGDMEN1 | |
| SCHEMBL15617108 | 0.90 | MAPT (0.82) | ALDH1A1KDM4EMAPTHPGDMEN1 | |
| SCHEMBL15617156 | 0.89 | ALDH1A1 (0.79) | ALDH1A1KDM4EMAPTHPGDMEN1 | |
| SCHEMBL15617119 | 0.89 | ALDH1A1 (0.79) | ALDH1A1KDM4EMAPTHPGDMEN1 | |
| SCHEMBL15617095 | 0.88 | ALDH1A1 (0.79) | ALDH1A1KDM4EMAPTHPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250346588-A1 | IMIDAZOPYRIDINE AND OXAZOLOPYRIDINE DERIVATIVES AND ANALOGS THEREOF, METHODS OF PREPARATION THEREOF, METHODS OF HIF-1/2A PATHWAY INHIBITION, AND INDUCTION OF FERROPTOSIS | KUDA THERAPEUTICS INC (US) | 2025-11-13 | — | — | US | claimed |
| EP-2890379-B1 | BENZOTHIAZOLE OR BENZOXAZOLE COMPOUNDS AS SUMO ACTIVATORS | ICAHN SCHOOL MED MOUNT SINAI (US) | 2019-04-03 | — | — | EP | claimed |
| US-20180127407-A1 | Benzothiazole Or Benzoxazole Compounds As Sumo Activators | ICAHN SCHOOL MED MOUNT SINAI (US) | 2018-05-10 | — | — | US | claimed |
| US-20150218148-A1 | Benzothiazole Or Benzoxazole Compounds As Sumo Activators | ICAHN SCHOOL MED MOUNT SINAI (US) | 2015-08-06 | — | — | US | claimed |
| EP-2890379-A2 | BENZOTHIAZOLE OR BENZOXAZOLE COMPOUNDS AS SUMO ACTIVATORS | Icahn School of Medicine at Mount Sinai (US) | 2015-07-08 | — | — | EP | claimed |
| WO-2014036242-A2 | BENZOTHIAZOLE OR BENZOXAZOLE COMPOUNDS AS SUMO ACTIVATORS | MOUNT SINAI SCHOOL OF MEDICINE (US) | 2014-03-06 | — | — | WO | claimed |
| US-20250346588-A1 | IMIDAZOPYRIDINE AND OXAZOLOPYRIDINE DERIVATIVES AND ANALOGS THEREOF, METHODS OF PREPARATION THEREOF, METHODS OF HIF-1/2A PATHWAY INHIBITION, AND INDUCTION OF FERROPTOSIS | KUDA THERAPEUTICS INC (US) | 2025-11-13 | — | — | US | disclosed |
| EP-4531838-A1 | IMIDAZOPYRIDINE AND OXAZOLOPYRIDINE DERIVATIVES AND ANALOGS THEREOF, METHODS OF PREPARATION THEREOF, METHODS OF HIF-1/2A PATHWAY INHIBITION, AND INDUCTION OF FERROPTOSIS | Kuda Therapeutics, Inc. (US) | 2025-04-09 | — | — | EP | disclosed |
| WO-2023234970-A1 | IMIDAZOPYRIDINE AND OXAZOLOPYRIDINE DERIVATIVES AND ANALOGS THEREOF, METHODS OF PREPARATION THEREOF, METHODS OF HIF-1/2A PATHWAY INHIBITION, AND INDUCTION OF FERROPTOSIS | KUDA Therapeutics, Inc. (US) | 2023-12-07 | — | — | WO | disclosed |
| US-11447482-B1 | Imidazopyridine and oxazolopyridine derivatives and analogs thereof, methods of preparation thereof, methods of HIF-2A pathway inhibition, and induction of ferroptosis | KUDA Therapeutics, Inc. (US) | 2022-09-20 | — | — | US | disclosed |
| US-20220281862-A1 | Imidazopyridine and Oxazolopyridine Derivatives and Analogs Thereof, Methods of Preparation Thereof, Methods of HIF-2A Pathway Inhibition, and Induction of Ferroptosis | KUDA Therapeutics, Inc. | 2022-09-08 | — | — | US | disclosed |
| US-20220281862-A1 | Imidazopyridine and Oxazolopyridine Derivatives and Analogs Thereof, Methods of Preparation Thereof, Methods of HIF-2A Pathway Inhibition, and Induction of Ferroptosis | KUDA Therapeutics, Inc. | 2022-09-08 | — | — | US | disclosed |
| EP-3524244-A1 | BENZOTHIAZOLE COMPOUNDS AS SUMO ACTIVATORS | Icahn School of Medicine at Mount Sinai (US) | 2019-08-14 | — | — | EP | disclosed |
| US-9845320-B2 | Benzothiazole or benzoxazole compounds as sumo activators | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2017-12-19 | — | — | US | disclosed |
| US-20150218148-A1 | Benzothiazole Or Benzoxazole Compounds As Sumo Activators | ICAHN SCHOOL MED MOUNT SINAI (US) | 2015-08-06 | — | — | US | disclosed |
| US-20150218148-A1 | Benzothiazole Or Benzoxazole Compounds As Sumo Activators | ICAHN SCHOOL MED MOUNT SINAI (US) | 2015-08-06 | — | — | US | disclosed |
| US-20150218148-A1 | Benzothiazole Or Benzoxazole Compounds As Sumo Activators | ICAHN SCHOOL MED MOUNT SINAI (US) | 2015-08-06 | — | — | US | disclosed |
| EP-2890379-A2 | BENZOTHIAZOLE OR BENZOXAZOLE COMPOUNDS AS SUMO ACTIVATORS | Icahn School of Medicine at Mount Sinai (US) | 2015-07-08 | — | — | EP | disclosed |
| WO-2014036242-A2 | BENZOTHIAZOLE OR BENZOXAZOLE COMPOUNDS AS SUMO ACTIVATORS | MOUNT SINAI SCHOOL OF MEDICINE (US) | 2014-03-06 | — | — | WO | disclosed |
| WO-2014036242-A2 | BENZOTHIAZOLE OR BENZOXAZOLE COMPOUNDS AS SUMO ACTIVATORS | MOUNT SINAI SCHOOL OF MEDICINE (US) | 2014-03-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250346588-A1 | IMIDAZOPYRIDINE AND OXAZOLOPYRIDINE DERIVATIVES AND ANALOGS THEREOF, METHODS OF PREPARATION THEREOF, METHODS OF HIF-1/2A PATHWAY INHIBITION, AND INDUCTION OF FERROPTOSIS | HIF1AN, HIF1A, EGLN2 | ALDH1A1 821/4885KDM4E 1020/4885MAPT 4577/4885 |
| US-11447482-B1 | Imidazopyridine and oxazolopyridine derivatives and analogs thereof, methods of preparation thereof, methods of HIF-2A pathway inhibition, and induction of ferroptosis | HIF1AN, HIF1A, EGLN2 | ALDH1A1 1144/4885KDM4E 686/4885MAPT 4642/4885 |
| US-20220281862-A1 | Imidazopyridine and Oxazolopyridine Derivatives and Analogs Thereof, Methods of Preparation Thereof, Methods of HIF-2A Pathway Inhibition, and Induction of Ferroptosis | HIF1AN, HIF1A, EGLN2 | ALDH1A1 1144/4885KDM4E 686/4885MAPT 4642/4885 |
| US-20150218148-A1 | Benzothiazole Or Benzoxazole Compounds As Sumo Activators | SUMO2, UBA2, SUMO1 | ALDH1A1 3054/4885KDM4E 1851/4885MAPT 1545/4885 |
| US-20180127407-A1 | Benzothiazole Or Benzoxazole Compounds As Sumo Activators | SUMO2, UBA2, SUMO1 | ALDH1A1 3054/4885KDM4E 1851/4885MAPT 1545/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.