Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.67 |
| ▸ | HPGD | P15428 | 7/20 | 0.67 |
| ▸ | LMNA | P02545 | 6/20 | 0.67 |
| ▸ | TP53 | P04637 | 5/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.67 |
| ▸ | RECQL | P46063 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 10/20 | 0.67 |
| ▸ | USP2 | O75604 | 1/20 | 0.67 |
| ▸ | GLA | P06280 | 1/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 11/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 11/20 | 0.62 |
| ▸ | NPC1 | O15118 | 6/20 | 0.62 |
| ▸ | RAB9A | P51151 | 6/20 | 0.62 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.62 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.62 |
| ▸ | RELA | Q04206 | 2/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15575468 | 0.84 | DUSP3 (0.80) | ALDH1A1SMN1; SMN2KDM4EHPGDLMNA | |
| SCHEMBL15575446 | 0.80 | ALDH1A1 (1.00) | ALDH1A1SMN1; SMN2KDM4EHPGDLMNA | |
| SCHEMBL15575498 | 0.80 | DUSP3 (0.71) | ALDH1A1SMN1; SMN2KDM4EHPGDLMNA | |
| SCHEMBL15575748 | 0.78 | DUSP3 (0.72) | ALDH1A1SMN1; SMN2KDM4EHPGDLMNA | |
| SCHEMBL15573992 | 0.78 | DUSP3 (0.74) | ALDH1A1SMN1; SMN2KDM4EHPGDLMNA | |
| SCHEMBL15575755 | 0.78 | ALDH1A1 (0.71) | ALDH1A1SMN1; SMN2KDM4EHPGDLMNA | |
| SCHEMBL20660102 | 0.77 | ALDH1A1 (0.85) | ALDH1A1SMN1; SMN2KDM4EHPGDLMNA | |
| SCHEMBL1307056 | 0.75 | MAPT (0.82) | ALDH1A1SMN1; SMN2KDM4EHPGDLMNA | |
| SCHEMBL15574005 | 0.75 | DUSP3 (0.70) | ALDH1A1SMN1; SMN2KDM4EHPGDLMNA | |
| SCHEMBL15575865 | 0.74 | MAPT (0.59) | ALDH1A1SMN1; SMN2KDM4EHPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2890379-B1 | BENZOTHIAZOLE OR BENZOXAZOLE COMPOUNDS AS SUMO ACTIVATORS | ICAHN SCHOOL MED MOUNT SINAI (US) | 2019-04-03 | — | — | EP | claimed |
| US-20180127407-A1 | Benzothiazole Or Benzoxazole Compounds As Sumo Activators | ICAHN SCHOOL MED MOUNT SINAI (US) | 2018-05-10 | — | — | US | claimed |
| US-20150218148-A1 | Benzothiazole Or Benzoxazole Compounds As Sumo Activators | ICAHN SCHOOL MED MOUNT SINAI (US) | 2015-08-06 | — | — | US | claimed |
| EP-2890379-A2 | BENZOTHIAZOLE OR BENZOXAZOLE COMPOUNDS AS SUMO ACTIVATORS | Icahn School of Medicine at Mount Sinai (US) | 2015-07-08 | — | — | EP | claimed |
| WO-2014036242-A2 | BENZOTHIAZOLE OR BENZOXAZOLE COMPOUNDS AS SUMO ACTIVATORS | MOUNT SINAI SCHOOL OF MEDICINE (US) | 2014-03-06 | — | — | WO | claimed |
| EP-3524244-A1 | BENZOTHIAZOLE COMPOUNDS AS SUMO ACTIVATORS | Icahn School of Medicine at Mount Sinai (US) | 2019-08-14 | — | — | EP | disclosed |
| EP-2890379-B1 | BENZOTHIAZOLE OR BENZOXAZOLE COMPOUNDS AS SUMO ACTIVATORS | ICAHN SCHOOL MED MOUNT SINAI (US) | 2019-04-03 | — | — | EP | disclosed |
| EP-2890379-B1 | BENZOTHIAZOLE OR BENZOXAZOLE COMPOUNDS AS SUMO ACTIVATORS | ICAHN SCHOOL MED MOUNT SINAI (US) | 2019-04-03 | — | — | EP | disclosed |
| US-20180127407-A1 | Benzothiazole Or Benzoxazole Compounds As Sumo Activators | ICAHN SCHOOL MED MOUNT SINAI (US) | 2018-05-10 | — | — | US | disclosed |
| US-9845320-B2 | Benzothiazole or benzoxazole compounds as sumo activators | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2017-12-19 | — | — | US | disclosed |
| US-9845320-B2 | Benzothiazole or benzoxazole compounds as sumo activators | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2017-12-19 | — | — | US | disclosed |
| US-9845320-B2 | Benzothiazole or benzoxazole compounds as sumo activators | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2017-12-19 | — | — | US | disclosed |
| US-20150218148-A1 | Benzothiazole Or Benzoxazole Compounds As Sumo Activators | ICAHN SCHOOL MED MOUNT SINAI (US) | 2015-08-06 | — | — | US | disclosed |
| US-20150218148-A1 | Benzothiazole Or Benzoxazole Compounds As Sumo Activators | ICAHN SCHOOL MED MOUNT SINAI (US) | 2015-08-06 | — | — | US | disclosed |
| US-20150218148-A1 | Benzothiazole Or Benzoxazole Compounds As Sumo Activators | ICAHN SCHOOL MED MOUNT SINAI (US) | 2015-08-06 | — | — | US | disclosed |
| EP-2890379-A2 | BENZOTHIAZOLE OR BENZOXAZOLE COMPOUNDS AS SUMO ACTIVATORS | Icahn School of Medicine at Mount Sinai (US) | 2015-07-08 | — | — | EP | disclosed |
| WO-2014036242-A2 | BENZOTHIAZOLE OR BENZOXAZOLE COMPOUNDS AS SUMO ACTIVATORS | MOUNT SINAI SCHOOL OF MEDICINE (US) | 2014-03-06 | — | — | WO | disclosed |
| WO-2014036242-A2 | BENZOTHIAZOLE OR BENZOXAZOLE COMPOUNDS AS SUMO ACTIVATORS | MOUNT SINAI SCHOOL OF MEDICINE (US) | 2014-03-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150218148-A1 | Benzothiazole Or Benzoxazole Compounds As Sumo Activators | SUMO2, UBA2, SUMO1 | ALDH1A1 3054/4885SMN1; SMN2 1481/4885KDM4E 1851/4885 |
| US-20180127407-A1 | Benzothiazole Or Benzoxazole Compounds As Sumo Activators | SUMO2, UBA2, SUMO1 | ALDH1A1 3054/4885SMN1; SMN2 1481/4885KDM4E 1851/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.