Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 8/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.40 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | KCNA3 | P22001 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19357459 | 0.88 | SMN1; SMN2 (0.45) | SMN1; SMN2MEN1KMT2AGAAOPRM1 | |
| SCHEMBL625405 | 0.88 | SMN1; SMN2 (0.45) | SMN1; SMN2MEN1KMT2AGAAOPRM1 | |
| SCHEMBL15577194 | 0.85 | NPSR1 (0.45) | SMN1; SMN2MEN1KMT2AGAAOPRM1 | |
| SCHEMBL6264708 | 0.83 | OPRM1 (0.43) | SMN1; SMN2MEN1KMT2AGAAOPRM1 | |
| SCHEMBL15862872 | 0.82 | GAA (0.41) | SMN1; SMN2MEN1KMT2AGAAOPRM1 | |
| SCHEMBL15577268 | 0.79 | GAA (0.42) | SMN1; SMN2MEN1KMT2AGAAOPRM1 | |
| SCHEMBL4407528 | 0.78 | TSHR (0.47) | OPRM1OPRD1OPRK1 | |
| SCHEMBL19031287 | 0.77 | HDAC4 (0.43) | SMN1; SMN2MEN1KMT2AGAAOPRM1 | |
| SCHEMBL15011161 | 0.76 | SLC6A4 (0.46) | SMN1; SMN2MEN1KMT2AGAAOPRM1 | |
| SCHEMBL627890 | 0.76 | OPRM1 (0.43) | SMN1; SMN2MEN1KMT2AGAAOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014041349-A1 | TETRAHYDROPYRAN-4-YLETHYLAMINO- OR TETRAHYDROPYRANYL-4-ETHYLOXY-PYRIMIDINES OR -PYRIDAZINES AS ISOPRENYLCYSTEINCARBOXYMETHYL TRANSFERASE INHIBITORS | CANCER THERAPEUTICS CRC PTY LTD (AU) | 2014-03-20 | — | — | WO | disclosed |
| WO-2014041349-A1 | TETRAHYDROPYRAN-4-YLETHYLAMINO- OR TETRAHYDROPYRANYL-4-ETHYLOXY-PYRIMIDINES OR -PYRIDAZINES AS ISOPRENYLCYSTEINCARBOXYMETHYL TRANSFERASE INHIBITORS | CANCER THERAPEUTICS CRC PTY LTD (AU) | 2014-03-20 | — | — | WO | disclosed |