Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 2/20 | 0.40 |
| ▸ | CLK1 | P49759 | 2/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24503717 | 0.85 | KIT (0.48) | PDPK1JAK2KMT2AHTTKDM4E | |
| SCHEMBL15577611 | 0.81 | PDPK1 (0.41) | PDPK1JAK2KMT2AHTTKDM4E | |
| SCHEMBL9939229 | 0.78 | ABL1 (0.53) | PDPK1JAK2KMT2AHTTKDM4E | |
| SCHEMBL15577824 | 0.75 | CLK1 (0.46) | PDPK1JAK2KMT2AHTTMAPT | |
| SCHEMBL2858453 | 0.73 | C1S (0.48) | PDPK1JAK2KMT2AHTTKDM4E | |
| SCHEMBL15577562 | 0.73 | ABL1 (0.38) | PDPK1JAK2KMT2AHTTKDM4E | |
| SCHEMBL28778104 | 0.72 | PTGES (0.45) | HTTKDM4EBACE1PABPC1 | |
| SCHEMBL17437190 | 0.72 | HTT (0.46) | PDPK1JAK2KMT2AHTTMEN1 | |
| SCHEMBL28301397 | 0.71 | KDM4E (0.50) | PDPK1KMT2AHTTKDM4EALDH1A1 | |
| SCHEMBL29627982 | 0.71 | ROCK1 (0.58) | PDPK1JAK2KMT2AHTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160257676-A1 | Aminoisoquinoline Derivatives as Protein Kinase Inhibitors | Eternity Bioscience Inc. (US) | 2016-09-08 | — | — | US | disclosed |
| US-20160257676-A1 | Aminoisoquinoline Derivatives as Protein Kinase Inhibitors | Eternity Bioscience Inc. (US) | 2016-09-08 | — | — | US | disclosed |
| US-20160257676-A1 | Aminoisoquinoline Derivatives as Protein Kinase Inhibitors | Eternity Bioscience Inc. (US) | 2016-09-08 | — | — | US | disclosed |
| EP-2895166-A1 | AMINOISOQUINOLINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | Eternity Bioscience Inc. (US) | 2015-07-22 | — | — | EP | disclosed |
| WO-2014043296-A1 | AMINOISOQUINOLINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | Eternity Bioscience Inc. (US) | 2014-03-20 | — | — | WO | disclosed |
| WO-2014043296-A1 | AMINOISOQUINOLINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | Eternity Bioscience Inc. (US) | 2014-03-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160257676-A1 | Aminoisoquinoline Derivatives as Protein Kinase Inhibitors | BRAF, RAF1, ARAF | PDPK1 118/4885JAK2 86/4885KMT2A 594/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.