SCHEMBL15580329

SCHEMBL15580329

CC(C)Oc1cc(Oc2ccc([PH](=O)OCOC(=O)C(C)(C)C)cc2)cc(C(=O)Nc2nccs2)c1

nearest known ligand 0.61

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GCK P35557 20/20 0.61
KCNH2 Q12809 2/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15580334 0.85 GCK (0.61) GCKKCNH2
SCHEMBL2656661 0.85 GCK (0.61) GCKKCNH2
SCHEMBL2657799 0.84 GCK (0.74) GCKKCNH2
SCHEMBL12021725 0.82 GCK (0.57) GCKKCNH2
SCHEMBL2656978 0.82 GCK (0.61) GCKKCNH2
SCHEMBL2658311 0.81 GCK (0.60) GCKKCNH2
SCHEMBL2657877 0.79 GCK (0.77) GCKKCNH2
SCHEMBL2669976 0.79 GCK (0.63) GCKKCNH2
SCHEMBL2666606 0.79 GCK (0.70) GCKKCNH2
SCHEMBL2658308 0.78 GCK (0.62) GCKKCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2185570-B1 NOVEL ACTIVATORS OF GLUCOKINASE METABASIS THERAPEUTICS INC (US) 2014-03-19 EP disclosed