Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16297553 | 1.00 | TSHR (0.50) | TSHR | |
| SCHEMBL5932513 | 0.85 | TSHR (0.46) | TSHR | |
| SCHEMBL7964460 | 0.83 | — | — | |
| SCHEMBL7100023 | 0.80 | TSHR (0.43) | TSHR | |
| SCHEMBL20629301 | 0.80 | TSHR (0.43) | TSHR | |
| SCHEMBL17919014 | 0.80 | TSHR (0.42) | TSHR | |
| SCHEMBL8125049 | 0.80 | TSHR (0.42) | TSHR | |
| SCHEMBL21754098 | 0.80 | TSHR (0.43) | TSHR | |
| SCHEMBL18388567 | 0.80 | TSHR (0.42) | TSHR | |
| SCHEMBL7961731 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2398789-B1 | SPIROPYRROLIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME (US) | 2014-03-19 | — | — | EP | disclosed |