Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.39 |
| ▸ | RPS6KA2 | Q15349 | 2/20 | 0.39 |
| ▸ | RPS6KA1 | Q15418 | 2/20 | 0.39 |
| ▸ | RPS6KA6 | Q9UK32 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 13/20 | 0.36 |
| ▸ | BUB1 | O43683 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL950208 | 0.90 | RPS6KA3 (0.40) | RPS6KA3RPS6KA2RPS6KA1RPS6KA6ALDH1A1 | |
| SCHEMBL19493244 | 0.88 | RPS6KA3 (0.39) | RPS6KA3RPS6KA2RPS6KA1RPS6KA6ALDH1A1 | |
| SCHEMBL950167 | 0.88 | RPS6KA3 (0.40) | RPS6KA3RPS6KA2RPS6KA1RPS6KA6ALDH1A1 | |
| SCHEMBL951161 | 0.85 | KLKB1 (0.41) | RPS6KA3RPS6KA2RPS6KA1RPS6KA6KLKB1 | |
| SCHEMBL950328 | 0.84 | SMN1; SMN2 (0.39) | KLKB1 | |
| SCHEMBL951302 | 0.84 | RAB9A (0.41) | RPS6KA3RPS6KA2RPS6KA1RPS6KA6ALDH1A1 | |
| SCHEMBL950926 | 0.84 | RPS6KA2 (0.41) | RPS6KA3RPS6KA2RPS6KA1RPS6KA6KLKB1 | |
| SCHEMBL19493245 | 0.83 | SMN1; SMN2 (0.38) | KLKB1 | |
| SCHEMBL947957 | 0.83 | RPS6KA2 (0.46) | RPS6KA3RPS6KA2RPS6KA1RPS6KA6ALDH1A1 | |
| SCHEMBL951005 | 0.82 | KDR (0.41) | RPS6KA3RPS6KA2RPS6KA1RPS6KA6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2294065-B1 | INDOLYL-PYRIDONE DERIVATIVES HAVING CHECKPOINT KINASE 1 INHIBITORY ACTIVITY | VERNALIS R&D LTD (GB) | 2014-03-19 | — | — | EP | disclosed |