SCHEMBL15580673

SCHEMBL15580673

C=Cc1cc(-c2ccc(C(=O)O)c(F)c2)ccc1[C@@H](C)[C@@](O)(c1cnc2c(c1)N(C)C(=O)CO2)C(F)(F)F

nearest known ligand 0.32

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
GPR55 Q9Y2T6 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL474467 0.89 GPR55 (0.34) GPR55
SCHEMBL12163888 0.89 GPR55 (0.34) GPR55
SCHEMBL474518 0.81 GPR55 (0.35) GPR55
SCHEMBL12163885 0.81 GPR55 (0.35) GPR55
SCHEMBL15520319 0.79 GPR55 (0.34) GPR55
SCHEMBL12163875 0.78 MALT1 (0.33) GPR55
SCHEMBL474282 0.78 MALT1 (0.33) GPR55
SCHEMBL15520825 0.77 GPR55 (0.35) GPR55
SCHEMBL2816563 0.77 GPR55 (0.39) GPR55
SCHEMBL2817590 0.77 GPR55 (0.39) GPR55

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2411365-B1 2,3-DIARYL- OR HETEROARYL-SUBSTITUTED 1,1,1-TRIFLUORO-2-HYDROXYPROPYL COMPOUNDS HOFFMANN LA ROCHE (CH) 2014-03-19 EP disclosed