GPR55

G-protein coupled receptor 55 · Q9Y2T6 · GPR55 on Sugi Atlas →

82,625 patent compounds predicted against GPR55, 55,775 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Cannabidivarin (SCHEMBL243338)	1.00	4/20
SCHEMBL112593	0.43	4/20
Cannabidiol (SCHEMBL119679)	1.00	3/20
Cannabidiol (SCHEMBL122259)	1.00	3/20
Helenalin (SCHEMBL161593)	1.00	3/20
Helenalin (SCHEMBL161594)	1.00	3/20
SCHEMBL169812	0.68	3/20
Oxyphenisatine (SCHEMBL239513)	0.58	3/20
SCHEMBL170128	0.52	3/20
SCHEMBL45826	0.52	3/20
SCHEMBL171820	0.51	3/20
SCHEMBL11752	0.50	3/20
SCHEMBL113902	0.45	3/20
SCHEMBL14801	0.44	3/20
SCHEMBL172169	0.37	3/20
Dronabinol (SCHEMBL4609)	1.00	2/20
Phenolphthalein (SCHEMBL27670)	1.00	2/20
Rimonabant (SCHEMBL38637)	1.00	2/20
Tetrahydrocannabivarin (SCHEMBL245827)	1.00	2/20
Phenolphthalein (SCHEMBL271736)	0.88	2/20

Clinical trials — most relevant to GPR55 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Investigating the Potential Role of Aerosolized Retinoic Acid, a Potent Vitamin A Metabolite for Treating COVID-19 Anosmia and Retinoic Acid Insufficiency .A Novel Approach for Regaining Sense of Smell.	PHASE4	UNKNOWN
Phase 3 Clinical Study of Chiauranib Capsule in Patients With Small-cell Lung Cancer	PHASE3	COMPLETED
Palmitoylethanolamide for Chronic Inflammatory Pain Conditions	PHASE2	RECRUITING
A Series of Pilot Studies to Evaluate the haemoDynamic and mEtabolic Effects oF apelIn aNd rElaxin	PHASE2	UNKNOWN
A Study With GW597599 And GR205171: Potential New Drugs For The Treatment Of Primary Insomnia	PHASE2	COMPLETED
A Study Investigating the Bioavailability of CBD and THC in an Emulsion Product in a Healthy Population	PHASE1	COMPLETED
A Study of CAR-GPRC5D in Patients With Relapsed/Refractory Multiple Myeloma or Plasma Cell Leukemia	PHASE1	RECRUITING
Role of the Gut Sweet Taste Receptor in the Secretion of Satiation Peptides	PHASE1	COMPLETED
Sweet Taste Receptors and the Secretion of Glucagon-like Peptide-1 and Peptide YY	PHASE1	COMPLETED
An Open Label Positron Emission Tomography (PET) Study to Determine Central mGluR5 Receptor Occupancy of AZD2516	PHASE1	COMPLETED
Evaluation of Two Radioactive Chemicals to Image mGluR5 Receptors in Brain	PHASE1	COMPLETED
Positron Emission Tomography (PET) Study With [11C]AZ12713580 to Determine Central mGluR5 Receptor Occupancy of AZD2066	PHASE1	COMPLETED
PET Imaging of Brain mGluR5 Receptors Using [18F]SP203	PHASE1	COMPLETED
Comparison of Cannabinoids to Placebo in Management of TMJ Pain and Myofascial Pain in the TMJ Region	nan	COMPLETED
Dose-response Effect of Pine Nut Oil as a Dual FFA1 and FFA4 Agonist on Glucose Tolerance in Healthy Humans.	nan	COMPLETED
FFAR Agonist on Incretins, Insulin, Lipids and Inflammation	nan	COMPLETED
Effect of Dietary Oils as G-protein-coupled Receptor Agonists on Glucose Tolerance	nan	UNKNOWN
Colonic Propionate, Appetite, and Weight Loss	nan	COMPLETED
Gut Microbiota and Modulation of Liver Damage in NAFLD	nan	COMPLETED
Neutrophil FFA2/GPR43 Receptor Expression in Patients With the Diagnosis of Sepsis	nan	WITHDRAWN
Oat Bran and Plasma Lipid and Fecal Bacteria in Coronary Artery Disease Patients	nan	COMPLETED
-Oleoyl Glycerol is a GPR119 Agonist and Signals GLP-1 Release in Humans.	nan	COMPLETED
Palmitoylethanolamide in Ulcerative Colitis	nan	NOT_YET_RECRUITING
Effects of Ozanimod on Immune-mediated Mechanisms of Neurodegeneration in Multiple Sclerosis - a Preclinical Study	nan	UNKNOWN
Investigating Optimal Propionate Delivery to the Colon Using Stable Isotope Labeling	nan	COMPLETED
Effects of Probiotics on Gut Microbiota, Endocannabinoid and Immune Activation and Symptoms of Fatigue in Dancers	nan	COMPLETED
RCT to Describe the Effects of Colon Delivered Acetate, Propionate and Butyrate on Satiety and Glucose Homeostasis	nan	COMPLETED
Vulvodynia: Identification of Potential Relevant Biomarkers	nan	COMPLETED
GPR109A and Parkinson's Disease: Role of Niacin in Outcome Measures	nan	COMPLETED
Selective Activation of the Adrenomedullin Receptors in Migraine	nan	NOT_YET_RECRUITING

Related proteins — ESM-2 sequence neighbours (a GPR55 binder may also engage these)

Protein	Name	Similarity
Q3UJF0	—	0.994	Q3UJF0 →
GPR174	Probable G-protein coupled receptor 174	0.988	landscape →
Q3U507	—	0.986	Q3U507 →
Q8C131	—	0.985	Q8C131 →
Q9XSD4	—	0.983	Q9XSD4 →
B2GV46	—	0.982	B2GV46 →
P2RY10	Putative P2Y purinoceptor 10	0.982	landscape →
Q80Z39	—	0.982	Q80Z39 →
D4A4Q2	—	0.981	D4A4Q2 →
HCAR1	Hydroxycarboxylic acid receptor 1	0.981	landscape →
CYSLTR2	Cysteinyl leukotriene receptor 2	0.981	landscape →
HCAR2	Hydroxycarboxylic acid receptor 2	0.981	landscape →
FFAR2	Free fatty acid receptor 2	0.979	landscape →
Q61038	—	0.979	Q61038 →
Q8BLG2	—	0.978	Q8BLG2 →
Q9EP66	—	0.978	Q9EP66 →
Q9Z282	—	0.978	Q9Z282 →
Q8BFU7	—	0.978	Q8BFU7 →
Q8BG55	—	0.977	Q8BG55 →
Q920A1	—	0.977	Q920A1 →
Q9GK76	—	0.977	Q9GK76 →
PTAFR	Platelet-activating factor receptor	0.977	landscape →
Q3UFD7	—	0.977	Q3UFD7 →
Q924T9	—	0.977	Q924T9 →
GPR132	Probable G-protein coupled receptor 132	0.977	landscape →
Q3U6B2	—	0.977	Q3U6B2 →
Q09QM4	—	0.976	Q09QM4 →
P21556	—	0.976	P21556 →
Q924T8	—	0.976	Q924T8 →
Q6NS65	—	0.976	Q6NS65 →