Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRIM24 | O15164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 9/20 | 0.36 |
| ▸ | PPARA | Q07869 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL474296 | 0.94 | TRIM24 (0.47) | TRIM24SMN1; SMN2PPARGPPARAKDM4E | |
| SCHEMBL12164048 | 0.94 | TRIM24 (0.47) | TRIM24SMN1; SMN2PPARGPPARAKDM4E | |
| SCHEMBL474253 | 0.89 | SMN1; SMN2 (0.40) | TRIM24SMN1; SMN2KDM4EMEN1KMT2A | |
| SCHEMBL12164042 | 0.89 | SMN1; SMN2 (0.40) | TRIM24SMN1; SMN2KDM4EMEN1KMT2A | |
| SCHEMBL12164058 | 0.82 | KMO (0.43) | TRIM24PPARGBRD4BRPF1 | |
| SCHEMBL474397 | 0.82 | ADORA2A (0.42) | SMN1; SMN2PPARAKDM4EMEN1KMT2A | |
| SCHEMBL474456 | 0.82 | KMO (0.43) | TRIM24PPARGBRD4BRPF1 | |
| SCHEMBL12164031 | 0.80 | SMN1; SMN2 (0.39) | TRIM24SMN1; SMN2PPARGPPARAKDM4E | |
| SCHEMBL474454 | 0.80 | SMN1; SMN2 (0.39) | TRIM24SMN1; SMN2PPARGPPARAKDM4E | |
| SCHEMBL474255 | 0.80 | BRD4 (0.38) | TRIM24SMN1; SMN2PPARGKDM4EBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411365-B1 | 2,3-DIARYL- OR HETEROARYL-SUBSTITUTED 1,1,1-TRIFLUORO-2-HYDROXYPROPYL COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2014-03-19 | — | — | EP | disclosed |