Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CMA1 | P23946 | 10/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.36 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.35 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | PPARD | Q03181 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL474551 | 0.94 | BRD4 (0.38) | CMA1BRD4BRPF1TRIM24S1PR2 | |
| SCHEMBL12164033 | 0.94 | BRD4 (0.38) | CMA1BRD4BRPF1TRIM24S1PR2 | |
| SCHEMBL474414 | 0.88 | CMA1 (0.36) | CMA1BRD4BRPF1TRIM24S1PR2 | |
| SCHEMBL12164036 | 0.88 | CMA1 (0.36) | CMA1BRD4BRPF1TRIM24S1PR2 | |
| SCHEMBL12164055 | 0.87 | BRPF1 (0.35) | CMA1BRD4BRPF1TRIM24S1PR2 | |
| SCHEMBL474489 | 0.87 | BRPF1 (0.35) | CMA1BRD4BRPF1TRIM24S1PR2 | |
| SCHEMBL474345 | 0.86 | BRD4 (0.36) | CMA1BRD4BRPF1TRIM24PPARG | |
| SCHEMBL12164056 | 0.86 | BRD4 (0.38) | CMA1BRD4BRPF1TRIM24PPARG | |
| SCHEMBL474255 | 0.86 | BRD4 (0.38) | CMA1BRD4BRPF1TRIM24PPARG | |
| SCHEMBL12163974 | 0.84 | CMA1 (0.36) | CMA1BRD4BRPF1ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411365-B1 | 2,3-DIARYL- OR HETEROARYL-SUBSTITUTED 1,1,1-TRIFLUORO-2-HYDROXYPROPYL COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2014-03-19 | — | — | EP | disclosed |