Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 17/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | CASP7 | P55210 | 1/20 | 0.50 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | MTOR | P42345 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15580743 | 0.87 | PIK3CA (0.67) | PIK3CAALDH1A1MAPK1HSD17B10CYP1A2 | |
| SCHEMBL13439633 | 0.87 | PIK3CA (0.64) | PIK3CAMTOR | |
| SCHEMBL189016 | 0.86 | PIK3CA (0.66) | PIK3CAALDH1A1MAPK1HSD17B10CYP1A2 | |
| SCHEMBL1901232 | 0.85 | PIK3CA (0.64) | PIK3CAALDH1A1MAPK1HSD17B10CYP1A2 | |
| SCHEMBL20614321 | 0.83 | PIK3CA (0.61) | PIK3CAALDH1A1MAPK1HSD17B10CYP1A2 | |
| SCHEMBL189610 | 0.81 | ALDH1A1 (0.67) | PIK3CAALDH1A1MAPK1HSD17B10CYP1A2 | |
| SCHEMBL3328432 | 0.81 | PIK3CA (0.76) | PIK3CAALDH1A1MAPK1HSD17B10CYP1A2 | |
| SCHEMBL1984055 | 0.80 | PIK3CA (0.84) | PIK3CAALDH1A1MAPK1HSD17B10CYP1A2 | |
| SCHEMBL13439726 | 0.80 | PIK3CA (0.64) | PIK3CAMTOR | |
| SCHEMBL3329698 | 0.79 | PIK3CA (1.00) | PIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139484-B9 | METHODS OF TREATING CANCER USING PYRIDOPYRIMIDINONE INHIBITORS OF PI3K ALPHA | EXELIXIS INC (US) | 2014-06-11 | — | — | EP | disclosed |