Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 11/20 | 0.43 |
| ▸ | CLK2 | P49760 | 9/20 | 0.43 |
| ▸ | CLK3 | P49761 | 8/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 5/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | WNT1 | P04628 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1558296 | 0.91 | MTOR (0.41) | DYRK1ACLK2CLK3KITMTOR | |
| SCHEMBL1559321 | 0.90 | MTOR (0.45) | DYRK1ACLK2CLK3MTORPIK3CD | |
| SCHEMBL1557556 | 0.84 | PIK3CA (0.41) | DYRK1AMTORPIK3CDPIK3CAPIK3CB | |
| SCHEMBL1558949 | 0.84 | CCNC (0.41) | DYRK1AMTORPIK3CDPIK3CAPIK3CB | |
| SCHEMBL1559250 | 0.82 | MTOR (0.43) | DYRK1AMTORPIK3CDPIK3CAPIK3CB | |
| Cyclopropane Carboxylic Acid SCHEMBL1557568 | 0.81 | CLK2 (0.45) | DYRK1ACLK2CLK3MTORWNT1 | |
| SCHEMBL2397709 | 0.81 | MTOR (0.42) | DYRK1ACLK2CLK3KITMTOR | |
| SCHEMBL2397682 | 0.80 | MTOR (0.45) | DYRK1ACLK2CLK3MTORPIK3CD | |
| SCHEMBL1559224 | 0.78 | MTOR (0.46) | MTORPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL1557599 | 0.77 | MTOR (0.42) | MTORPIK3CDPIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2303890-A2 | PHOSPHATIDYLINOSITOL 3 KINASE INHIBITORS | Progenics Pharmaceuticals, Inc. (US) | 2011-04-06 | — | — | EP | disclosed |
| WO-2009155527-A9 | PHOSPHATIDYLINOSITOL 3 KINASE INHIBITORS | PROGENICS PHARMACEUTICALS, INC. (US) | 2010-05-06 | — | — | WO | disclosed |
| WO-2009155527-A2 | PHOSPHATIDYLINOSITOL 3 KINASE INHIBITORS | PROGENICS PHARMACEUTICALS, INC. (US) | 2009-12-23 | — | — | WO | disclosed |