Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK2 | P49760 | 7/20 | 0.45 |
| ▸ | CLK3 | P49761 | 6/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.45 |
| ▸ | WNT1 | P04628 | 11/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1558652 | 0.88 | MTOR (0.46) | CLK2CLK3DYRK1AWNT1MTOR | |
| SCHEMBL1557471 | 0.87 | CLK2 (0.44) | CLK2CLK3DYRK1AWNT1MTOR | |
| Cyclopropane Carboxylic Acid SCHEMBL1557567 | 0.83 | CLK2 (0.48) | CLK2CLK3DYRK1AWNT1MTOR | |
| SCHEMBL1558238 | 0.82 | PIK3CA (0.41) | CLK2DYRK1AMTOR | |
| SCHEMBL1558752 | 0.81 | DYRK1A (0.43) | CLK2CLK3DYRK1AWNT1MTOR | |
| SCHEMBL1558766 | 0.80 | CDK7 (0.47) | DYRK1AMTOR | |
| SCHEMBL1559107 | 0.79 | MTOR (0.46) | DYRK1AMTOR | |
| SCHEMBL1559035 | 0.79 | MTOR (0.36) | DYRK1AMTOR | |
| SCHEMBL1558686 | 0.78 | XDH (0.47) | DYRK1AWNT1MTOR | |
| SCHEMBL1559352 | 0.78 | DDR2 (0.50) | MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2303890-A2 | PHOSPHATIDYLINOSITOL 3 KINASE INHIBITORS | Progenics Pharmaceuticals, Inc. (US) | 2011-04-06 | — | — | EP | disclosed |
| WO-2009155527-A9 | PHOSPHATIDYLINOSITOL 3 KINASE INHIBITORS | PROGENICS PHARMACEUTICALS, INC. (US) | 2010-05-06 | — | — | WO | disclosed |
| WO-2009155527-A2 | PHOSPHATIDYLINOSITOL 3 KINASE INHIBITORS | PROGENICS PHARMACEUTICALS, INC. (US) | 2009-12-23 | — | — | WO | disclosed |