Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8002161 | 0.69 | KDM4E (0.49) | GAAKDM4EALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL12501217 | 0.66 | GAA (0.47) | GAAKDM4EALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL24533861 | 0.66 | HDAC4 (0.33) | — | |
| SCHEMBL12410860 | 0.65 | GAA (0.56) | GAAKDM4EALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL12410705 | 0.65 | GAA (0.46) | GAAKDM4EALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL12714105 | 0.63 | — | — | |
| SCHEMBL23529915 | 0.62 | GAA (0.47) | GAAKDM4EALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL14167172 | 0.59 | POLB (0.32) | KDM4EALDH1A1 | |
| SCHEMBL8544450 | 0.58 | HTT (0.47) | GAAKDM4EALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL8544598 | 0.58 | LMNA (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014031936-A2 | HETEROCYCLIC MODULATORS OF HIF ACTIVITY FOR TREATMENT OF DISEASE | JONES PHILIP (US) | 2014-02-27 | — | — | WO | disclosed |