Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 20/20 | 0.43 |
| ▸ | SCN5A | Q14524 | 10/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15599161 | 0.81 | S1PR1 (0.40) | SCN9A | |
| SCHEMBL15599286 | 0.79 | SCN9A (0.45) | SCN9ASCN5ACYP3A4CYP2C9 | |
| SCHEMBL10332075 | 0.79 | SMN1; SMN2 (0.39) | CYP2C9 | |
| SCHEMBL16082402 | 0.79 | SCN9A (0.44) | SCN9ASCN5ACYP3A4CYP2C9 | |
| SCHEMBL10324676 | 0.78 | SCN9A (0.44) | SCN9ASCN5ACYP3A4CYP2C9 | |
| SCHEMBL16858566 | 0.78 | SCN9A (0.44) | SCN9ASCN5ACYP3A4CYP2C9 | |
| SCHEMBL17244885 | 0.78 | SCN9A (0.44) | SCN9ASCN5ACYP3A4CYP2C9 | |
| SCHEMBL365208 | 0.78 | SCN9A (0.47) | SCN9ASCN5ACYP3A4CYP2C9 | |
| SCHEMBL21031212 | 0.77 | HCRTR1 (0.44) | SCN9ACYP2C9 | |
| SCHEMBL15599248 | 0.77 | CSNK2A1 (0.34) | CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9550775-B2 | Substituted triazolopyridines and methods of use thereof | GENENTECH, INC. (US) | 2017-01-24 | — | — | US | disclosed |
| WO-2014153037-A1 | SUBSTITUTED TRIAZOLOPYRIDINES AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2014-09-25 | — | — | WO | disclosed |
| WO-2014008458-A2 | N-SUBSTITUTED BENZAMIDES AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2014-01-09 | — | — | WO | disclosed |