Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | APP | P05067 | 4/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15599217 | 0.79 | SSTR4 (0.38) | HTR2AHTR2CLRRK2CYP17A1CYP11B1 | |
| SCHEMBL10332075 | 0.79 | SMN1; SMN2 (0.39) | HTR2AHTR2CSMN1; SMN2LMNACYP2C9 | |
| SCHEMBL15599157 | 0.79 | SMN1; SMN2 (0.39) | SMN1; SMN2LMNAPTGS2MRGPRX4 | |
| SCHEMBL21031212 | 0.77 | HCRTR1 (0.44) | SMN1; SMN2LMNACYP2C9TSHRAPEX1 | |
| SCHEMBL15599250 | 0.77 | SCN9A (0.43) | CYP2C9 | |
| SCHEMBL15599247 | 0.76 | PTGS2 (0.36) | SMN1; SMN2LMNARXRAGRIN1GRIN2B | |
| SCHEMBL18400155 | 0.76 | PTGS2 (0.36) | SMN1; SMN2LMNACYP2C9TSHRAPEX1 | |
| SCHEMBL15599195 | 0.75 | IDH1 (0.33) | HTR2AHTR2CCYP17A1CYP11B1CYP11B2 | |
| SCHEMBL15599161 | 0.75 | S1PR1 (0.40) | CSNK2A1RORC | |
| SCHEMBL18400077 | 0.74 | SCN9A (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014153037-A1 | SUBSTITUTED TRIAZOLOPYRIDINES AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2014-09-25 | — | — | WO | disclosed |
| WO-2014144545-A2 | SUBSTITUTED BENZOXAZOLES AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2014-09-18 | — | — | WO | disclosed |
| WO-2014008458-A2 | N-SUBSTITUTED BENZAMIDES AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2014-01-09 | — | — | WO | disclosed |