Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.47 |
| ▸ | AHR | P35869 | 4/20 | 0.45 |
| ▸ | CMA1 | P23946 | 2/20 | 0.45 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.44 |
| ▸ | CACNG8 | Q8WXS5 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.42 |
| ▸ | MMP12 | P39900 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14346061 | 0.81 | EIF2AK2 (0.45) | EIF2AK2AHRCMA1GRIA1CACNG8 | |
| SCHEMBL278958 | 0.80 | AHR (0.61) | PKMEIF2AK2AHRCMA1GRIA1 | |
| SCHEMBL433708 | 0.80 | AHR (0.61) | PKMAHRCMA1GRIA1CACNG8 | |
| SCHEMBL30796831 | 0.80 | AHR (0.59) | EIF2AK2AHRCMA1GRIA1CACNG8 | |
| SCHEMBL12125841 | 0.80 | PARP1 (0.46) | PKMEIF2AK2AHRCMA1GRIA1 | |
| SCHEMBL17177657 | 0.74 | AHR (0.42) | EIF2AK2AHRCMA1GRIA1CACNG8 | |
| SCHEMBL31010750 | 0.73 | AHR (0.59) | EIF2AK2AHRCMA1GRIA1CACNG8 | |
| SCHEMBL13529011 | 0.72 | CRBN (0.61) | EIF2AK2AHRCMA1GRIA1CACNG8 | |
| SCHEMBL1436084 | 0.72 | GRIA1 (0.53) | PKMEIF2AK2AHRCMA1GRIA1 | |
| SCHEMBL10274620 | 0.71 | EPHX2 (0.55) | PKMAHRGRIA1CACNG8CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140080833-A1 | INTRACELLULAR KINASE INHIBITORS | MANNKIND CORPORATION (US) | 2014-03-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140080833-A1 | INTRACELLULAR KINASE INHIBITORS | PI4KB, BTK, LTK | PKM 1323/4885EIF2AK2 344/4885AHR 4194/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.