Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | ABL1 | P00519 | 2/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.40 |
| ▸ | BCR | P11274 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.35 |
| ▸ | TEK | Q02763 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | USP7 | Q93009 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1560165 | 0.89 | ABL1 (0.41) | NPC1RAB9AABL1ABCB1BCR | |
| SCHEMBL1558934 | 0.89 | NPC1 (0.41) | NPC1RAB9AABL1ABCB1BCR | |
| SCHEMBL1559111 | 0.82 | NPC1 (0.37) | NPC1RAB9ATP53MAPTNFKB1 | |
| SCHEMBL1937723 | 0.81 | ABL1 (0.38) | NPC1RAB9AABL1ABCB1BCR | |
| SCHEMBL1559578 | 0.79 | CYP1A1 (0.35) | NPC1RAB9AABL1ABCB1BCR | |
| SCHEMBL1559520 | 0.77 | CTSA (0.35) | TP53MAPTTSHRPDE2APDE10A | |
| SCHEMBL1560195 | 0.77 | MAPT (0.45) | NPC1RAB9AABL1ABCB1BCR | |
| SCHEMBL1560637 | 0.76 | CTSA (0.36) | TP53MAPTCYP11B1USP7CYP1A1 | |
| SCHEMBL1560628 | 0.76 | ERN1 (0.37) | TP53MAPTCYP1A1CYP1B1 | |
| SCHEMBL1560532 | 0.76 | CTSA (0.34) | TP53MAPTPDE2APDE10ACYP1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110092544-A1 | FUNGICIDAL PYRIDINES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2011-04-21 | — | — | US | claimed |
| EP-2303843-A2 | FUNGICIDAL PYRIDINES | E. I. du Pont de Nemours and Company (US) | 2011-04-06 | — | — | EP | claimed |
| WO-2009158257-A2 | FUNGICIDAL PYRIDINES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2009-12-30 | — | — | WO | claimed |
| US-20110092544-A1 | FUNGICIDAL PYRIDINES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2011-04-21 | — | — | US | disclosed |
| EP-2303843-A2 | FUNGICIDAL PYRIDINES | E. I. du Pont de Nemours and Company (US) | 2011-04-06 | — | — | EP | disclosed |
| WO-2009158257-A2 | FUNGICIDAL PYRIDINES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2009-12-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110092544-A1 | FUNGICIDAL PYRIDINES | CBR3, CBR1, CYP8B1 | NPC1 367/4885RAB9A 2297/4885ABL1 616/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.