Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 10/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.57 |
| ▸ | CYP46A1 | Q9Y6A2 | 3/20 | 0.57 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.49 |
| ▸ | USP2 | O75604 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.46 |
| ▸ | LSS | P48449 | 1/20 | 0.45 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14849079 | 0.84 | CYP46A1 (0.78) | CYP3A4CYP2C9CYP46A1CYP2C8CYP2C19 | |
| SCHEMBL15612235 | 0.83 | CYP46A1 (0.56) | CYP3A4CYP2C9CYP46A1CYP2C8CYP2C19 | |
| SCHEMBL15612176 | 0.77 | CYP46A1 (0.56) | CYP3A4CYP2C9CYP46A1CYP2C8CYP2C19 | |
| Soticlestat SCHEMBL14841089 | 0.73 | CYP46A1 (1.00) | CYP3A4CYP2C9CYP46A1CYP2C8CYP2C19 | |
| Soticlestat SCHEMBL29469585 | 0.73 | CYP46A1 (1.00) | CYP3A4CYP2C9CYP46A1CYP2C8CYP2C19 | |
| SCHEMBL14849069 | 0.72 | CYP46A1 (0.74) | CYP3A4CYP2C9CYP46A1CYP2C8CYP2C19 | |
| Soticlestat SCHEMBL31653945 | 0.72 | CYP46A1 (0.98) | CYP3A4CYP2C9CYP46A1CYP2C8CYP2C19 | |
| SCHEMBL14849089 | 0.72 | CYP46A1 (1.00) | CYP3A4CYP2C9CYP46A1CYP2C8CYP2C19 | |
| Soticlestat SCHEMBL20473188 | 0.72 | CYP46A1 (0.98) | CYP3A4CYP2C9CYP46A1CYP2C8CYP2C19 | |
| SCHEMBL22728300 | 0.72 | CYP46A1 (0.79) | CYP3A4CYP2C9CYP46A1CYP2C8CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8871766-B2 | Heterocyclic compounds | TAKEDA PHARMACEUTICAL CO., LTD. (JP) | 2014-10-28 | — | — | US | disclosed |
| US-20140088118-A1 | HETEROCYCLIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2014-03-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140088118-A1 | HETEROCYCLIC COMPOUNDS | HTT, NQO1, BDNF | CYP3A4 3310/4885CYP2C9 3038/4885CYP46A1 1579/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.