BDNF

Neurotrophic factor BDNF precursor form · P23560 · BDNF on Sugi Atlas →

2,344 patent compounds predicted against BDNF, 931 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL13431410 SCHEMBL13431410 0.72 3/20
SCHEMBL13431419 SCHEMBL13431419 0.72 3/20
SCHEMBL13596864 SCHEMBL13596864 0.72 3/20
SCHEMBL13431408 SCHEMBL13431408 0.71 3/20
SCHEMBL13431409 SCHEMBL13431409 0.70 3/20
SCHEMBL13431418 SCHEMBL13431418 0.70 3/20
SCHEMBL13431469 SCHEMBL13431469 0.70 3/20
SCHEMBL13431406 SCHEMBL13431406 0.69 3/20
SCHEMBL14208653 SCHEMBL14208653 0.65 3/20
SCHEMBL13431399 SCHEMBL13431399 0.65 3/20
SCHEMBL18914908 SCHEMBL18914908 0.64 3/20
SCHEMBL17167232 SCHEMBL17167232 0.61 3/20
SCHEMBL13321926 SCHEMBL13321926 0.61 3/20
SCHEMBL13321885 SCHEMBL13321885 0.61 3/20
SCHEMBL13431412 SCHEMBL13431412 0.61 3/20
SCHEMBL13431415 SCHEMBL13431415 0.61 3/20
SCHEMBL13431465 SCHEMBL13431465 0.61 3/20
SCHEMBL13321878 SCHEMBL13321878 0.61 3/20
SCHEMBL13431401 SCHEMBL13431401 0.60 3/20
SCHEMBL13431404 SCHEMBL13431404 0.60 3/20

Clinical trials — most relevant to BDNF by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Effect of Oxcarbazepine on Serum Brain Derived Neurotrophic Factor (BDNF) in Bipolar Disorder PHASE4COMPLETED
Comparison of Antidepressant Augmentation With Amantadine vs Pramipexole vs Quetiapine in Treatment Resistant Depression PHASE4UNKNOWN
Brain Derived Neurotrophic Factor as a Predictor of Response to Treatment in Bipolar Depression and Mania: 16-weeks Follow-up With Quetiapine XR PHASE3UNKNOWN
Study to Assess Safety and Efficacy of Fingolimod in Children With Rett Syndrome PHASE1/PHASE2COMPLETED
Comparative Study to Test Safety and Efficacy of Neurotrophic and Cholinergic Treatment of Alzheimer's Disease PHASE2COMPLETED
Cilostazol in Parkinson's Disease PHASE2NOT_YET_RECRUITING
Effects of Mepivacaine on the Neurological Sequelae of Cerebral Infarction PHASE2UNKNOWN
An Open-label, Exploratory Study to Investigate the Efficacy of BDNF Essentials® on Cognition PHASE1COMPLETED
Psychoneuromentalism Disorder: A Medical Condition That Affects People With Psychological Impairments From Health Issues EARLY_PHASE1NOT_YET_RECRUITING
Anxiety and Depression Disorder in Patient Treated With rTPA for Mangment of Acute Ischemic Stroke nanUNKNOWN
IGF and Other Neurotrophic Factors in Patients With Dementia nanCOMPLETED
Effects of Exercise on Functional Performance, BDNF, Executive Functions and Sleep Quality in Children with Epilepsy nanNOT_YET_RECRUITING
Epigenetic Regulation of BDNF in Major Depression nanCOMPLETED
Molecular Markers of Neuroplasticity During Exercise in People With Incomplete Spinal Cord Injury nanCOMPLETED
Study of the Effect of Antidepressant Drugs on Neurotrophic Factors in Patients With Depression nanCOMPLETED
Brain Derived Neurotrophic Factor as a Predictor of Response to Treatment in Bipolar Depression and Mania nanUNKNOWN
Moderate Intensity Aerobic Training in Sub-acute and Chronic Stroke Patients - the Influence on Brain Derived Neurotrophic Factor (BDNF) and Upper-limb Rehabilitation. A Protocol for a Randomized Control Trial and Health Economic Evaluation nanCOMPLETED
Effect of Intraoperative Sedation on PND in Elderly Patients nanUNKNOWN
The Phosphodiesterase-3 Inhibitor Cilostazol as an Adjunctive to Antidepressants in Patients With Major Depressive Disorder. nanCOMPLETED
The Effects of Exercise on Serum BDNF and Irisin Levels in Patients With Rheumatoid Arthritis nanCOMPLETED
Investigating Neurocognitive, Motor and Biological Effects of MindLenses Professional in Neurological Diseases nanCOMPLETED
pCO2 Oscillations During Exercise: Relation to Cerebral Blood Flow and to Cognitive Dysfunction in COPD nanCOMPLETED
Blood Neurotrophic Factors in Adults nanWITHDRAWN
Cognitive Remediation in Schizophrenia: Efficacy and Role of Neuroplasticity in Top-down and Bottom-up Mechanisms nanRECRUITING
NTRK 1,2,3 Rearrangements in Patients With Solid Tumors nanACTIVE_NOT_RECRUITING
Research on Pathophysiology and Treatment in Depression Using Brain Derived Neurotrophic Factor and Amyloid Neuroimaging nanUNKNOWN
Therapeutic Use of rTMS in Pediatric ASD and ADHD Cohorts nanRECRUITING
Effects of Genetic Variation on the Efficacy of Aerobic Exercise nanCOMPLETED
Understanding How Cognitive Remediation Works nanCOMPLETED
Brain-Induced Neurotrophic Factor Levels in Patients Undergoing Coronary Artery Bypass Surgery nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a BDNF binder may also engage these)

ProteinNameSimilarity
Q3SAT7 1.000 Q3SAT7 →
P25429 1.000 P25429 →
P20783 1.000 P20783 →
O18753 1.000 O18753 →
Q4L0Y3 1.000 Q4L0Y3 →
Q5IS78 1.000 Q5IS78 →
O97759 1.000 O97759 →
O70183 1.000 O70183 →
O18755 1.000 O18755 →
Q7YRB4 1.000 Q7YRB4 →
Q6LCI5 1.000 Q6LCI5 →
Q1HN38 1.000 Q1HN38 →
Q49M28 1.000 Q49M28 →
Q95106 1.000 Q95106 →
O18752 1.000 O18752 →
P20181 1.000 P20181 →
Q1X6Z6 1.000 Q1X6Z6 →
Q1HN40 1.000 Q1HN40 →
P21237 1.000 P21237 →
P18280 1.000 P18280 →
P23363 1.000 P23363 →
Q1X705 1.000 Q1X705 →
P14082 1.000 P14082 →
P25435 1.000 P25435 →
Q1HN32 1.000 Q1HN32 →
P24727 1.000 P24727 →
Q8QG74 1.000 Q8QG74 →
Q9TST3 1.000 Q9TST3 →
Q1HN36 0.999 Q1HN36 →
P25433 0.999 P25433 →