Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | CASP6 | P55212 | 1/20 | 0.59 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.57 |
| ▸ | CDKN1A | P38936 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | BRD3 | Q15059 | 4/20 | 0.53 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16941536 | 0.89 | GAA (0.65) | GAACASP6SIRT1CDKN1ARECQL | |
| SCHEMBL15614732 | 0.89 | CDKN1A (0.64) | GAACASP6SIRT1CDKN1ARECQL | |
| SCHEMBL15614787 | 0.84 | GAA (0.60) | GAACASP6SIRT1RECQLSIRT2 | |
| SCHEMBL15577178 | 0.84 | GAA (0.60) | GAACASP6SIRT1RECQLSIRT2 | |
| SCHEMBL16946169 | 0.84 | CYP2D6 (0.74) | GAACASP6SIRT1CDKN1ARECQL | |
| SCHEMBL4156108 | 0.84 | CYP2D6 (0.74) | GAACASP6SIRT1CDKN1ARECQL | |
| SCHEMBL4161447 | 0.82 | BRD3 (0.77) | GAACASP6SIRT1CDKN1ARECQL | |
| SCHEMBL16941533 | 0.81 | GAA (0.56) | GAACASP6SIRT1CDKN1ARECQL | |
| SCHEMBL4148059 | 0.80 | MAPT (0.63) | GAACASP6SIRT1SIRT2CYP2D6 | |
| SCHEMBL16433445 | 0.80 | CYP2D6 (0.79) | GAACASP6SIRT1RECQLSIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150210717-A1 | SPECIFIC INHIBITORS OF PROTEIN P21 AS THERAPEUTIC AGENTS | LEIBNIZ-INSTITUT FÜR ALTERSFORSCHUNG (DE) | 2015-07-30 | — | — | US | disclosed |
| WO-2014041125-A1 | SPECIFIC INHIBITORS OF PROTEIN P21 AS THERAPEUTIC AGENTS | BADEN-WÜRTTEMBERG STIFTUNG GMBH (DE) | 2014-03-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150210717-A1 | SPECIFIC INHIBITORS OF PROTEIN P21 AS THERAPEUTIC AGENTS | CDKN1A, ING2, BCCIP | GAA 3655/4885CASP6 1933/4885SIRT1 870/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.